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Oregano oil and its carvacrol theraputic power as the most effective infection and inflamation depresent. How the right diet, reinforced with vitamins D and C (not ascorbic acid!) can subdue infection and inflamation. ENDOCRINE SYSTEM AND MICROBIOTA Page Content The Endocrine System The Hypothalamic–Pituitary–Thyroid axis The Hypothalamic–Pituitary–Adrenal axis Thyroid Disorders Hypothyroidism In Infants Thyroid's Health Melatonin and the Pineal Gland The endocrine system synthesizes and secrete hormones to regulate physiological processes. Interestingly the gut microbiome is an endocrine organ itself; metabolomic and metagenomic studies have revealed bacterial metabolites and components that affect organ function and subsequently, physiological outcomes. Endocrine System ENDOCRINE SYSTEM, GUT MICROBIOME AND OTHER DISRUPTORS Gut microbiome and the Endocrine (Glands Hormones) System A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on the functioning of the endocrine system.This study concludes "Likewise, a role for the microbiota in the regulation of the HPA axis has been established as well as the serotonergic system via modulation of tryptophan availability. Unlike other endocrine organs, the microbiota has intense plasticity and can alter dramatically and rapidly in response to diet." Note ! "hypothalamic-pituitary-adrenal (HPA) axis, an intricate, yet robust, neuroendocrine mechanism that mediates the effects of stressors by regulating numerous physiological processes, such as metabolism, immune responses, and the autonomic nervous system (ANS)"More spicifically, "The composition of the gut microbiota has an influence on the availability of essential micronutrients for the thyroid gland.Iodine, iron, and copper are crucial for thyroid hormone synthesis, selenium and zinc are needed for converting T4 to T3, and vitamin D assists in regulating the immune response". The damage incurred to gut microbiota by drugs in general and antibiotic drugs in particular! The human gut microbiota has now been proved to be closely associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. Some drugs with microbial features, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest impact and associations with the microbiome. Read more The Hypothalamic–Pituitary–Thyroid axis (HPT) axis, is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress. The interdependence between thyroid hormones, namely, thyroxine and triiodothyronine, and immune system is nowadays well-recognized . Thyroid diseases are common conditions that have a negative impact on the health of all populations. The literature sheds light on the differences in the composition of the intestinal microbiota in patients suffering from thyroid diseases compared to healthy individuals. The Hypothalamic–Pituitary–Adrenal (HPA) axis is emerging to closely interact with the gut microbiota. The hypothalamic-pituitary-adrenal (HPA) axis is a complex neuroendocrine system that plays a crucial role in the body's stress response and homeostasis regulation . Here's an overview of its key components and functions: 1. Hypothalamus 2. Pituitary gland 3. Adrenal glands When the body perceives stress, the following cascade of events occurs: The paraventricular nucleus of the hypothalamus releases corticotropin-releasing hormone (CRH) and vasopressin[1 ][3 ]. CRH stimulates the anterior lobe of the pituitary gland to secrete adrenocorticotropic hormone (ACTH)[1 ][3 ]. ACTH travels through the bloodstream to the adrenal cortex, where it stimulates the production and release of glucocorticoids, primarily cortisol in humans[1 ][3 ]. Functions and Regulation The HPA axis serves several important functions: Stress response: It mediates the body's physiological adaptation to stressors[1 ][2 ]. Homeostasis: It regulates various body processes, including metabolism, immune responses, and energy balance[1 ]. Circadian rhythm: It plays a role in maintaining the body's daily rhythms[2 ]. The HPA axis is regulated through negative feedback loops : Elevated cortisol levels inhibit further HPA axis activation by suppressing CRH and ACTH production in the hypothalamus and pituitary gland, respectively[3 ]. This feedback mechanism helps maintain appropriate cortisol levels and prevents overactivation of the stress response[3 ]. Clinical Significance Dysregulation of the HPA axis can lead to various health issues: Chronic stress can result in prolonged activation of the HPA axis, potentially leading to anxiety, depression, and other mood disorders[2 ]. Abnormal HPA axis function has been implicated in inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis[1 ]. HPA axis dysfunction may contribute to metabolic disorders and cardiovascular diseases[2 ]. Understanding the HPA axis is crucial for comprehending the physiological effects of stress and the potential long-term consequences of chronic stress on overall health and well-being. Low levels of gonadal circulating estrogen (Gonads are glands that produce hormones involved in reproduction and other functions of the body) observed in post-menopausal women can adversely impact a diverse range of physiological factors, with clinical implications for brain cognition, gut health, the female reproductive tract and other aspects of women's health. One of the principal regulators of circulating estrogens is the gut microbiome . "Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models." Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoing an additional transition: pregnancy, which may or may not be accompanied by breastfeeding. These endocrinological transitions exert significant effects on the immune system due to interactions between the hormonal milieu, innate, and adaptive immune systems as well as pro- and anti-inflammatory cytokines, and thereby modulate the susceptibility of women to autoimmune diseases. "The human gut-resident commensal microbiota (our indigenous bacteria ) is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis (imbalance of gut microbiota associated with an unhealthy outcome ) plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases." This study (one out of many) "describes the bidirectional communication between the gut microbiota and the HPA (Hypothalamic–Pituitary–Adrenal) axis and delineates the potential underlying mechanisms." This Study , "discuss how the intestinal bacterial microbiome and in particular how an 'estrobolome,' the aggregate of enteric bacterial genes capable of metabolizing estrogens, might affect women's risk of developing postmenopausal estrogen receptor-positive breast cancer ." The above citations and references are presented to convince you that healthy gut microbiota is a prime element in the maintenance of healthy endocrine system. For more about HEALTHY MICROBIOTA read on this page. The Hypothalamic–Pituitary–Thyroid axis The Hypothalamic–Pituitary–Adrenal (HPA) axis Thyroid Disorder - Hypothyroidism Thyroid Disorder - Hypothyroidism A condition, typically affects people over 60 and is more common among women than men, where the thyroid gland no longer produces enough of the important metabolism-controlling hormones. Without the right amount of thyroid hormones the T4 and T3 ones, your body’s natural functions – like your cognitive functioning (Read more ) and metabolism – start deteriorating. T4 (thyroxine) and T3 (triiodothyronine) are crucial thyroid hormones that play vital roles in regulating various bodily functions. Here's an overview of their roles and importance: Metabolic Regulation T4 and T3 are essential for controlling metabolism throughout the body. They influence how cells use energy and regulate the body's overall metabolic rate[1 ][2 ]. This impacts various processes, including: Protein synthesis: Thyroid hormones help regulate protein production in cells. Carbohydrate metabolism: They influence how the body processes and uses carbohydrates. Fat metabolism: T3 and T4 play a role in fat breakdown and utilization. Growth and Development Thyroid hormones are critical for: Brain development: Especially crucial during fetal development and early childhood. Physical growth: They influence bone growth and maturation. Organ Function T3 and T4 affect the function of nearly every organ system in the body, including: Cardiovascular system: Regulating heart rate and cardiac output. Respiratory system: Influencing breathing rate and lung function. Digestive system: Affecting gut motility and nutrient absorption. Nervous system: Impacting cognitive function and mood. Temperature Regulation Thyroid hormones help maintain body temperature by influencing heat production and energy expenditure[2 ]. Hormone Interplay T4 as a prohormone: T4 serves primarily as a reservoir for T3, the more biologically active form[1 ]. Conversion process: Most T3 is produced by converting T4 to T3 in peripheral tissues, particularly the liver and kidneys[3 ]. Thyroid-Progesterone Interactions - The thyroid and progesterone can influence each other in several ways: Thyroid hormones affect the metabolism of steroid hormones, including progesterone. Hypothyroidism may lead to increased progesterone levels in some men. Progesterone can influence thyroid hormone binding in the bloodstream. Both hormones play roles in male fertility and reproductive function. Feedback Loop T3 and T4 participate in a complex feedback system involving the hypothalamus, pituitary gland, and thyroid gland to maintain hormonal balance[2 ][4 ]. Clinical Significance Imbalances in T3 and T4 levels can lead to various thyroid disorders: Hypothyroidism: Insufficient thyroid hormone production, leading to symptoms like fatigue, weight gain, and cold intolerance[5 ]. Hyperthyroidism: Excessive thyroid hormone production, causing symptoms such as anxiety, weight loss, and heat intolerance[5 ]. Understanding the roles of T3 and T4 is crucial for diagnosing and managing thyroid disorders, as well as comprehending their wide-ranging effects on overall health and well-being. Does hypothyroidism cause high cortisol (don't confuse it with cholesterol) levels? It has long been k nown that hypothyroidism causes elevated cortisol levels , presumably due to both decreased clearance and blunted negative feedback of cortisol on the hypothalamic-pituitary-adrenal axis. Hashimoto’s Thyroiditis In Hashimoto’s Thyroiditis, the immune system mistakenly attacks the thyroid gland. Over time, these autoimmune attacks destroy healthy thyroid tissue, reducing thyroid hormone production. Hashimoto’s thyroiditis is the most common cause of underactive thyroid in the United States. And while it mostly affects middle-aged women, it can affect anyone at any age. Hypothyroidism In Infants Although hypothyroidism most often affects middle-aged and older women, anyone can develop the condition, including infants. Initially, babies born without a thyroid gland or with a gland that doesn't work properly may have few signs and symptoms. When newborns do have problems with hypothyroidism, the problems may include: Yellowing of the skin and whites of the eyes (jaundice). In most cases, this occurs when a baby's liver can't metabolize a substance called bilirubin, which normally forms when the body recycles old or damaged red blood cells. A large, protruding tongue. Difficulty breathing. Hoarse crying. An umbilical hernia. As the disease progresses, infants are likely to have trouble feeding and may fail to grow and develop normally. They may also have: Constipation Poor muscle tone Excessive sleepiness When hypothyroidism in infants isn't treated, even mild cases can lead to severe physical and mental retardation. Hypothyroidism in children and teens In general, children and teens who develop hypothyroidism have the same signs and symptoms as adults do, but they may also experience: Poor growth, resulting in short stature Delayed development of permanent teeth Delayed puberty Poor mental development Hyperthyroidism is a condition causing your thyroid to produce too much thyroid hormone. This can cause normal bodily processes to speed up, such as your heart rate. It can also lead to weight loss and difficulty sleeping. Hyperthyroidism is far less common than hypothyroidism, affecting less than 1% of people over the age of 12. Just like hypothyroidism, though, hyperthyroidism tends to affect women and men over the age of 60. Thyroid Health : There are some supplements that could help with thyroid general health like Selenium (a mineral needed for thyroid hormone production), Iodine, Zinc, and Iron. BUT, first and foremost, its health is closely linked to a healthy body and gut microbiota - actions for microbiota health are prescribed on this linked page . Note! "the composition of the gut microbiota has an influence on the availability of essential micronutrients for the thyroid gland. Iodine, iron, and copper are crucial for thyroid hormone synthesis, selenium and zinc are needed for converting thyroxine (the thyroid hormone - T4) to triiodothyronine hormone (T3), and vitamin D assists in regulating the immune response. Those micronutrients are often found to be deficient in Autoimmune Thyroid Disease patients (AITDs), resulting in malfunctioning of the thyroid. Bariatric surgery can lead to an inadequate absorption of these nutrients and further implicates changes in thyroid stimulating hormone (TSH) and T3 levels. Supplementation of probiotics showed beneficial effects on thyroid hormones and thyroid function in general..." Read more here . Hypothyroidism In Infants Thyroid Health Melatonin and the Pineal Gland Melatonin and the Pineal Gland The Melatonin hormone , often referred to as the sleep hormone, is a central part of the body’s sleep-wake cycle. Its production increases with evening darkness, promoting healthy sleep and helping to orient the body’s circadian rhythm. Two forms of melatonin exist in the body – circulatory (produced by the pineal gland), and subcellular (produced inside the cells and mitochondria); the majority of melatonin in the body is subcellular. Absence of light stimulates production of melatonin from the pineal gland, however, the largest stimulus of subcellular melatonin is near infrared light (sunshine is the greatest source - Roughly 49% of solar radiation is infrared between 700nm-1mm!). Note! The antioxidant effects of melatonin are so strong, they are thought to be strong and more potent than glutathione [REF1 ], Vitamin C [REF2 ], and Vitamin E. Melatonin is also being studied in other areas of health, such as neurodegenerative diseases, cancers, and anti-aging in general

SHILAJIT Nature's Best "Juice" Shilajit is nature's health gift! Our shilajit is top quality above 75% fulvic acid, less than 6% water content, thanks to our Himalayan mining grounds (Leh Ladakh, Altitude: Above 17450 ft) and our ayurvedic processing 100% PURE HIMALAYAN SHILAJIT, ABOVE 75% FULVIC ACID, LESS THAN 6% VISCOSITY 30 grams 13.99 USD Product details This resin is in its purest form without any artificial additives, Above 75% Fulvic acid, Strictly ayurvedic processing, Product viscosity may vary somewhat with water content between 5%-6%. FROM ROCK TO RESIN SHOPPING FOR SHILAJIT, THESE ITEMS MAKE A BIG DIFFERENCE : HARVESTED IN THE HIMALAYAN "NUMBERS", NOT WORDS OF FULVIC ACID AND WATER (VISCOSITY) CONTENT - THE HIGHER THE WATER CONTENT - THE LESS SHILAJIT IN THE JAR! Himalayan shilajit and Altai shilajit are both natural substances that are used for a variety of health benefits. Both are derived from the same source - the breakdown of plants in the Himalayas and the Altai mountains, respectively - but there are some key differences between the two that make Himalayan shilajit superior. First, Himalayan shilajit is more pure and potent than Altai shilajit. This is because it is sourced from the higher and more remote regions of the Himalayas, which means it is less likely to be contaminated by pollutants or other impurities. In contrast, Altai shilajit is sourced from the lower and more accessible regions of the Altai mountains, which means it is more susceptible to contamination. Second, Himalayan shilajit is more carefully processed and tested than Altai shilajit. This is because it is produced by experienced and reputable manufacturers who use strict quality control measures to ensure the purity and potency of their products. In contrast, Altai shilajit is often produced by less experienced and less reputable manufacturers who may not use the same level of quality control. Third, Himalayan shilajit has been extensively studied and proven to be effective for a wide range of health benefits. This is because it has been used for centuries in traditional Ayurvedic medicine, and has been the subject of numerous scientific studies that have demonstrated its effectiveness. In contrast, Altai shilajit has not been as extensively studied, and therefore its effectiveness for various health benefits is not as well established. Overall, Himalayan shilajit is the superior choice over Altai shilajit due to its purity, potency, careful processing, and proven effectiveness. It is the better option for those looking to experience the many health benefits of shilajit. Shilajit's health benefits studies: Chronic fatigue : Shilajit attenuates behavioural symptoms of chronic fatigue syndrome. Low testosterone level : Clinical evaluation of purified Shilajit on testosterone levels in healthy volunteers “testosterone in a randomised, double-blind, placebo-controlled clinical study at a dose of 250 mg twice a day. Treatment with Shilajit for consecutive 90 days revealed that it has significantly (P < 0.05) increased total testosterone, free testosterone and dehydroepiandrosterone (DHEAS) compared with placebo.” Read this study about the "Relationship between serum total testosterone and prostate volume in ageing men". Reduce signs of ageing : Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit. Shilajit: A Natural Phytocomplex with Potential Procognitive Activity Read here the abstracts of many scientific studies confirming shilajit's effectiveness in many health related aging signs Antiarthritic : Shilajit is also found to be very beneficial in rheumatoid arthritis, osteoarthritis, and gout Osteoporosis and bone tissue : The effects of shilajit extract on cell proliferation and enzyme expression of human osteoblast-like cells. The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation Effects of shilajit on the b one tissue of alcohol administered rats. gastrointestinal function Shilajit Improves gastrointestinal function : Copied from the abstract of this study (one of many that investigated the shilajit benefits to the human gastrointestinal function): "Traditional medicine and modern research claim Fulvic Acid can modulate the immune system, influence the oxidative state of cells, and improve gastrointestinal function; all of which are hallmarks of diabetes". ADULTS USAGE The daily recommended dosage of the resin for adults - men and women with normal body mass index and average health is 250 - 500 mg, taken in the morning on empty stomach. Some "experienced" users take up to 3 grams per day.

Lectin, Gluten, Phytic Acid, Emulsifiers Page Content: Lectins Lectins Removal Gluten Gluten Removal Phytic Acid Phytic Acid Removal Emulsifiers Sprouting to Remove Lectins Related Linked Pages: Rice and Arsenic Glyphosate Back to Prevention Back to Risky Foods... Lectins Lectins Lectins are a type of carbohydrate-binding protein . “Plants have evolved to produce chemical compounds—like lectins—to repel microorganisms, insects, and other pests.[ 2 ]” . Lectins are plant compounds most commonly found in legumes, potatoes and nightshade vegetables. For many people, lectins could cause intestinal damage and inflammation, Lectins and the Gut Microbiota - “Some lectins may affect the gut microbiota as well as having systemic effects such as the modulation of inflammation and immune function[17 ,18 ].” Dietary lectins are powerful exogenous growth factors for the small intestine, can induce dramatic shifts in its bacterial flora, and interfere with its hormone secretion. In addition, lectins which are transported across the gut wall into the systemic circulation can modulate the body's hormone balance, metabolism and health. Although these physiological effects are mediated or reinforced by immune responses, they are primarily the result of the specific chemical reactivity of lectins with cell surface receptors of the gut. Clearly, as the interactions between lectins and the gut are predictable and may be manipulated to our advantage, the exciting scientific challenge is now to explore the possible transfer of the existing knowledge gained from animal experimentation to medical-clinical practice. Lectins Removal - To make it short, lectin removal is linked to a diet change. To learn more about your options in that direction, we recommend to watch a short video by Dr. Gundry who is considered as one of the leading experts in this field. To put it shortly,Lectin removal from vegetables such as squash, cucumber, eggplant, pepper and tomatoes can be achieved by removing the skins and seeds. Cooking, especially with wet high-heat methods like boiling or stewing, or soaking in water for several hours, can inactivate most lectins. Gluten Gluten is part of the lectin protein “family”. Wheat, rye, barley and oat are some of the seeds with high gluten that are most commonly used in many processed foods. Gluten and Neurodegeneration - “On the gut level , gluten enhances intestinal permeability by compromising functional tight junction integrity resulting in a leaky gut [12,16,18,45].” “Gluten consumption affects microbiome/dysbiome composition and diversity [38,45,49]. The cross-reactivity of anti-gluten/-gliadin/-wheat antibodies with cerebral molecules further attest for the gut-brain axes connecting those heavily consumed nutrients to chronic brain conditions. “Despite the paucity of evidence establishing a causal relationship between dietary gluten intake and neurological disorders, a number of studies demonstrate an association between the 2 and/or a beneficial effect on neurological symptoms when gluten is restricted from the diet [2 ]” Gluten Removal - “Here, the authors report the results of a randomised cross-over trial involving middle-aged, healthy Danish adults, showing evidence that a low-gluten diet leads to gut microbiome changes, possibly due to variations in dietary fibres.” Bottomline, eliminating or drastically reducing gluten intake in our diet is important to our health. Unlike other lectins, soaking, sprouting or boiling does not significantly reduce gluten from the hosting seed (wheat, ray…), so the only option left is to drastically reduce the intake of processed foods that are made from these seeds.[1 ] Phytic acid, This acid is the primary way phosphorus is stored in many plants, including beans, seeds, and nuts. See the table in this article for more details about phytic acid content in various seeds. When phytic acid is consumed , it binds to other minerals to create phytates. Because you don't have any enzymes that can break phytates down, the minerals that are absorb into them are no longer available to our body. People sometimes refer to phytic acid as an anti-nutrient, because it blocks the absorption of certain minerals into the body. When you eat foods with high content of phytic acid, the molecules bind with certain minerals in our digestive tract, including Calcium, Magnesium, Iron, Zinc, Chromium and Manganese. Once this occurs, our body no longer has access to these nutrients. Generally, the more phytic acid we eat, the more minerals are blocked from our body. Read more here for detailed Phytic acid content of various seed types. However, recent studies have shown that phytic acid's anti-nutrient effect occurs only when large amounts of phytates are consumed within a diet that is already lacking nutrition, given that “most phytate (37-66%) is degraded in the stomach and small intestines”. It also only affects the absorption of nutrients eaten at the same meal. Phytic Acid Removal As presented in this article , Soaking (overnight) and sprouting could be most effective to reduce the Phytic Acid content of most “seeds”. Emulsifiers Dietary Emulsifiers alter the composition and activity of the Human Gut Microbiota , irrespective of their origin, be it chemical or natural. Here are two different ways in which the emulsifiers attack the delicate and ancient ecosystem in the intestine: They are physically abusive , or literally "peel off" the mucous layer on the wall of the intestine. Such an injury naturally leads to a more leaky gut, systemic inflammation... and a lot of suffering and chronic illness. They change the community of intestinal bacteria , and impair their function as the "keepers" of the guts intelligent barrier. As we know from many other examples, damage to the microbiome and the intestinal wall also leads to various damage to the brain and behavior, so it is not surprising that an experiment on mice showed that the emulsifying substances change their behavior and causes anxiety! Lectins Removal Gluten Gluten Removal Phytic Acid Phytic Acid Removal Emulsifiers

The Danger of Cooking and Baking Bags Page Content: What material is used for the bags Leakage of nano particles from the bag Plastic Extra Substances Phthalates in the plastic Toxins "Spilled" from the Plastic Bags Cooking/baking bag alternatives First and foremost, to avoid any misconception, these bags are made out of plastic, and the question discussed below is: Are these bags safe to use ? Given that most Plastic Products Release Estrogenic Chemicals ? Related Linked Pages: Microwave and Foods Plastics At Home Aluminum Foil Health Risks Rice and Arsenic Glyphosate Back to Prevention Back to Risky Foods... Lectin, Gluten, Phytic Acid, Emulsifiers What material is used for the bags Leakage of plastic nano prticles Plastic Extra Substances Regulatory limits change from time to time. The discussion below brings to light some of the risks of these nanometer-sized particles. Additionally , "Previous studies have shown that some plastic materials, including polypropylene used for baby bottles and polyethylene terephthalate used for tea bags, can shed microscopic and nanoscale particles into heated liquids", Note that some of the health problems with synthetic polymers come from the extra substances (toxins) inside the matrix that can migrate out of it! Plastic Extra Substances Some of these extra substances are add to improve the polymer’s “qualities”: Plasticisers - materials that, among other things, give flexibility and strength to the bag. These are substances with small molecules that can easily migrate from the plastic medium, especially in the presence of oil. The most commonly used are phthalates of various kinds . (Read here more about phthalates ), Potential problems: phthalates are substances that act as synthetic hormones (endocrine disruptors) and can bind to estrogen receptors in our body and activate or paralyze them . Antioxidant substances - which protect against oxidation processes such as exposure to UV radiation, free radicals formed at high heat (for example during baking), exposure to infrared radiation and microwave radiation, and more. Among the commonly used substances is bisphenol A (BPA ), which also acts as a synthetic hormone that binds to estrogen receptors in our body.(Read More ) Lubricants - which, among other things, prevent adhesion, reduce friction, reduce static electricity, increase shine and transparency, and more. The common materials for this role are synthetic fatty acids, wax and more (Read More ). Most of the cooking/baking bags are made of polyamides ( nylon ) of two main types: nylon 6 (polycaprolactam) or nylon 6/6 (a completely different material despite the similar name). These types of nylon were chosen for the job due to being resistant to high temperatures (melting temperature of 218 degrees and 264 degrees Celsius for nylon 6 and nylon 6/6 respectively), due to their high vapor permeability and due to their ability to actually absorb water during use (a feature that gives them more strength). The manufacturers of the baking bags do not bother to indicate, neither on the packaging nor on their websites, what exactly they add to the production of the baking bag, therefore we do not have information about this or that brand, but information about baking bags in general. Beware the nanoparticles leakage : Nylon cooking bags and plastic-lined cardboard cups are conveniences many people rely on! , A new study (Published - April 2022) in ACS’ Environmental Science & Technology suggests that they are an underappreciated source of nanoparticles. They report that the plastic in these products release trillions of nanometer-sized particles into each liter of water that they come in contact with. That sounds like a lot, but the team notes that these levels are under the regulatory limits for consumption. Phthalates in the plastic Materials "Spilled" from the Plastic Bags Cooking/baking bags alternatives Some are residual materials from the production process: Monomers and oligomers that did not react in the production process - there is almost always a residual amount of monomers and oligomers (remember? structural units with short and medium molecules), either due to an incomplete chemical process or due to a chemical equilibrium in which there is always a bit of the opposite reaction (decomposition instead of construction) . These substances can have a wide range of toxicity depending on the type of substance due to their high ability to migrate out of the medium of the substance into the food. In the case of the nylons in question - the monomer caprolactam is found in nylon 6 and is toxic if swallowed , and the monomers found in nylon 6/6 are hexamethylenediamine which is toxic if swallowed , and adipic acid for which there is no indication of toxicity if swallowed (R ead More ). Some are materials that are not there on purpose but originate from an unclean production line. Of course, manufacturers would claim that these toxins are not added to their polymer products, but even if these claims are trustworthy (Read here more on how trustworthy they are), the toxins that are the result of unclean production line, can only be discovered with certainty by an analytical test in a laboratory and unfortunately, the authorities responsible for public health do not perform these tests. In summary of the above - the common cooking/baking bags have a high potential for leaking very problematic toxins most notably Phthalates that are endocrine disruptors - acting in the body like hormones! Phthalates “Phthalates are a series of widely used chemicals that demonstrate to be endocrine disruptors and are detrimental to human health . Phthalates can be found in most products that have contact with plastics during production, packaging, or delivery. Despite the short half-lives in tissues, chronic exposure to phthalates will adversely influence the endocrine system and functioning of multiple organs, which has negative long-term impacts on the success of pregnancy, child growth and development, and reproductive systems in both young children and adolescents”. The field of environmental hormone disruptors is a relatively new field of research in the world of toxicology. For this reason and in light of the unique property of toxicity even at minute doses of individual particles per million or even a billion (which are very, very low concentrations) - there are still no current standards, nor Sufficiently sensitive and available measurement means, which can give both the manufacturers and us the consumers a benchmark for the product's safety Toxins "Spilled" from the Plastic Bags What did studies that looked for spillage of specific materials from baking bags find? In a 1998 study that was done to test the migration of materials from baking bags of the nylon 6 and nylon 6/6 types, the meat, skin and cooking juices of chicken cooked in the above types of bags were sampled. They tried to identify both volatile and non-volatile substances that migrated from the bags to the food. The study found a significant concentration of monomers and oligomers (seven predefined types of monomers and oligomers were identified) originating from the bags in the chicken meat which accounted for 16% of all the non-volatile substances identified, as well as the presence of a volatile compound - cyclopentyl cyclopentanone! In 1997, The same group of researchers has identified a long list of volatile substances emitted from the aforementioned cooking bags [Cyclopentanone (31.7 mg/bag), cyclopentyl cyclopentanone (17.4 mg/bag), hexadecane (2.6 micrograms/bag), heptadecane (3.2 micrograms/bag), octadecane (3.0 micrograms/bag) and epsilon-caprolactam (5.0-35.5 mg/ bag)], and also that the monomers and oligomers found in the first study mentioned, migrated in a high amount to olive oil heated in the baking bags. Another study from 2007 that examined a specific leakage of antimony (heavy metal) used as a catalyst in the production process of PET plastic used for baking bags, found that half of the products tested released levels of antimony that exceeded the then permitted level of antimony in contact with food. Note, what WIKI writes "An oven bag, cooking bag or roasting bag is a bag used for the roasting of meat or other food in an oven. They may be made of heatproof nylon or sometimes with food grade polyethylene terephthalate (PET)" To sum it up : The studies as presented above show that there is a leakage of toxic substances from cooking/baking bags. Cooking bags alternatives : Oven roasting using heat-resistant dishes with lids such as pyrex, coated clay pots or cast iron pots, tagine, and more, after validating that they comply with the standard for heavy metals and are of high quality. You can also use cotton fabric bags for cooking (with adjustment of the amount of water that you add to the stew).

Glyphosate Page Content: Background Glyphosate Be Aware Actions to Avoid Exposure to Herbicides Related Linked Pages: Lectin, Gluten and Phytic Acid Rice and Arsenic Back to Risky Foods... Back to Prevention Background There are many toxins that may reach our plate, the kindergarten and the backyard. Here we will focus on the most obvious and blatant of them all: the common herbicides. Background Herbicides contain highly toxic active ingredients whose toxicity has been studied for years. The most well-known active ingredient, almost a star, is glyphosate and its salts, which are also found in many pesticides. The most well-known of these herbicides is Roundup - a brand name of a systemic, broad-spectrum glyphosate-based herbicide originally produced by Monsanto. Glyphosate So we focus here on glyphosate , but, to the best of our knowledge, all herbicides are toxic and contain, in addition to the active ingredient, toxic surfactants and other substances. The IARC (International Agency for Research on Cancer and the World Health Organization) officially announced “The herbicide glyphosate and the insecticides malathion and diazinon were classified as probably carcinogenic to humans (Group 2A)." It turns out that glyphosate is linked to the development of non-Hodgkins lymphoma, and one study even found that there was an increase in markers for DNA damage among residents of a residential neighborhood where the substance was sprayed, that is, an immediate reaction upon exposure to the substance. Many other health issues have been linked to glyphosate exposure including disruption of critical enzymatic processes, harming the production of important neurotransmitters for the brain, autism , celiac disease, gluten intolerance, irritable bowel syndrome and severe damage to the intestinal flora, hormonal disruptions, and many other diseases [Read more ],. Dr. Steffanie Seneff (PHD), who has been researching for three decades the connection between the increase in the use of glyphosate and the increase in autism rates among children in the US and China has found a direct connection between the rates of autism that are rising at an alarming rate in the United States and the increase in the scope of children's exposure to glyphosate. As soon as it was declared to be a carcinogenic substance, glyphosate was outlawed in leading European countries (Germany, the Netherlands) which immediately called for a blanket ban by the European Union on the use of the substance. Glyphosate is not volatile, is very soluble in water and has an excellent ability to bind to the soil. It can remain in the soil for a considerable period of time (half-life varies between 30 - 100 days) where it undergoes slow decomposition by microorganisms in the soil, and in water even slower due to a significantly lower concentration of microorganisms. The material is stated toxic to humans, and also found to be highly toxic for aquatic plants, and for marine creatures . Exposure to this herbicide is primarily through: Direct spraying on vegetation near our home / the kindergarten / the playground / the sides of roads and sidewalks / agricultural fields Respiratory exposure - during the spraying itself, a spray is carried in the air that is very easy to sense its presence due to its chemical aroma. So that immediately during the spraying and immediately after it there can be respiratory exposure to anyone passing by (and of course to the gardener spraying himself). Eating genetically modified food - a much more difficult and disturbing way of exposure! It turns out that in many crops, including soybeans, soya, wheat, corn and many many more (including non-edible crops such as cotton, etc.), they found a brilliant way to get rid of unwanted vegetation without harming the crops, using seeds with injected genes resistance to glyphosate, growers can spray the crops (and the growing ground) eliminating the weeds, and getting weeds “clean” crops growth. By doing so the crops become saturated with glyphosate in all their tissues, also transfer it to the fruits and seeds - and from there to our plate! And so a path of exposure through ingestion opens up to us, which is probably the main factor behind the increase in the rates of serious diseases, autism, and possibly even cancer . Be Aware! As spring time arrives, many plants start to wake up and grow at a fast pace in order to have time to set seeds before the arrival of the dry summer. Many of these plants are medicinal or edible. They grow in fields and open areas, but also on the sides of sidewalks and roads, and practically anywhere possible. For the most part, these valuable plants are seen as "weeds" and almost as quickly as they grew, people wearing spray cans appear everywhere on the paths, in the gardens, even kindergartens, and in the public areas, spraying chemical substances on the plants and the soil in order to prevent the unwanted growth of the plants of the season. There is no malice here, as this automatic act is done in order to destroy potential hiding places for dangerous snakes and insects (so it is claimed). But there is not too much thinking outside of the concept here, and certainly there is no awareness of the great risk that these substances pose - both to the sprayers and to the public exposed to these areas. Note! It turns out that some authorities send gardeners to urban kindergartens who arrive without prior notice or coordination, with master keys to the kindergartens. They exterminate the weeds in the garden without any hindrance, sometimes without the knowledge of the gardener and certainly without the knowledge of the parents, sometimes right during activities in the garden! Actions to Avoid Exposure to Herbicides Start consuming organic crops! Look for the non GMO label confirming that this is a natural product or check with the manufacturer if this label is missing (yes, call the customer service centers!). In the home garden - do not spray! In the kindergarten - talk to the gardeners, to avoid spaying! Also Make sure that kindergarteners do not arrive without the presence of the kindergarten teacher If you have already sprayed - ask the gardeners what substance they used and look for details on the net about the active substance. Spread a generous layer of live compost over the sprayed area (if you don't have it at home and you buy it, make sure it's not sterilized but live) in order to enrich the poisoned soil with microorganisms that will accelerate the decomposition. Water generously to help the compost percolate and to keep the toxic material away from near the surface. Actions to Avoid Exposure to Herbicides Be Aware Glyphosate

how to keep our microbiome healthy, to help these bacteria perform it key role in healthy functioning of organs such as the brain, heart, thyroid and many others. Body and Gut Microbiom Page Content: Gut microbiome and our immune system Gut Microbiome Related Health Issues Microbiome and related Health issues Microbiome recovery and maintenance Fermented foods - Home Making Benefits of Scoby Derivatives Home making of scob y drinks Home making of kefir milk Antibiotics and Our Microbiome Additional Diet Change actions The role of Gluten and Sugar Fresh Vegetables Omega-3 Our gastrointestinal tract is now considered one of the most complex microbial ecosystems on earth, and its influence is such that it’s frequently referred to as our “second brain." Nearly 100 trillion bacteria, fungi, viruses and other microorganisms compose our gut microbiome, and advancing science has made it quite clear that these organisms play a major role in our health, both mental and physical. There are more bacterial cells in your body than human cells, but the ratio isn’t as extreme as once thought. A 2016 study at the Weizmann Institute of Science in Israel found that our total cell count is 56 per cent bacteria (compared with earlier estimates of 90 per cent). And because bacteria are much smaller, their total mass is only about  200g. So by weight, we are more than 99.7 per cent human, and there is more bacterial DNA than human DNA. Read more The gut microbiome has a most critical impact on our health through its strong link to the functioning of our heart, brain, endocrine system, liver , immune system and the functioning of the digestive system itself. GUT MICROBIOME AND OUR IMMUNE SYSTEM The gut microbiota, is the largest symbiotic ecosystem with the host. It has been shown to play important roles in maintaining and regulating the intestinal and immune homeostasis . Recently it became obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Read m ore " Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models." Dysbiosis of the gut microbiome is caused by the imbalance between the commensal (indigenous bacteria) and pathogenic microbiomes. The commensal microbiome regulates the maturation of the mucosal immune system (the largest component of the entire immune system), while the pathogenic microbiome causes immunity dysfunction, resulting in disease development. The gut mucosal immune system, which consists of lymph nodes, lamina propria and epithelial cells, constitutes a protective barrier for the integrity of the intestinal tract. The composition of the gut microbiota is under the surveillance of the normal mucosal immune system. Inflammation, which is caused by abnormal immune responses, influences the balance of the gut microbiome, resulting in intestinal diseases. In this review, we briefly outlined the interaction between the gut microbiota and the immune system and provided a reference for. ( Read more ) Selenium and zinc are needed for converting T4 to T3, and vitamin D assists in regulating the immune response "The damage incurred to gut microbiota by drugs in general and antibiotic drugs in particular! The human gut microbiota has now been proved to be closely associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. Some drugs with microbial features, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest impact and associations with the microbiome. Read more Gut Microbiome Related Health Issues - To name a few: Prostate problems , dark skin , athlete’s foot , various eye conditions , and the list goes on! The above linked studies (and many more) show that for many of us, some of these problems can be related to one common issue – gut microbiome imbalance . There are diverse expert opinions for solutions but our recommended kombucha/jun daily intake is definitely a good start. At the end of the day it is all very personal. Sharing your own personal experience in the customer review section below could definitely help. Many studies have linked certain gut microbes to autoimmune disease, in which the immune system mistakenly attacks the body’s own tissues. Read more Fischbach says that many afflictions, from Crohn’s to cardiovascular disease, may be caused by dysfunction or imbalances in our microbial communities ( Read more ). About 1 million people in the United States have ulcerative colitis, a serious disease of the colon that has no cure and whose cause is obscure. Now, a study by Stanford University School of Medicine investigators has tied the condition to a missing microbe. Immune system and microbiome Gut Microbiome Related Health Issues Microbiome Recovery and Maintenance Microbiome Recovery and Maintenance HOME MAKING OF FERMENTED FOODS Sauerkraut - Simple to make and most beneficial - "Microbial Community Analysis of Sauerkraut Fermentation Reveals a Stable and Rapidly Established Community ", to make it simple, fermented cabbage is a great cheap and simple for home making source for good microbiome, most notably, the Lactobacillus which "strengthen intestinal barrier function by increasing mucus production". 32 Seconds sauerkraut recipe: Cut the cabbage into 4 sections, Remove the "hard part" from each section, Cut the "cleaned" section into large pieces, Put all the pieces into a Jar with a cover (a Clip Top Storage jar is most convenient), Fill the jar with salt water - 30 grams salt per liter, making sure that the water covers the cabbage, Close the jar and let it ferment for a week. Fermented Pickles - "Cucumber fermentation is traditionally done using lactic acid bacteria. The involvement of probiotic cultures in food fermentation guarantees enhanced organoleptic properties and protects food from spoilage." Fermented foods - home making Boost: Fermented foods Stanford researchers (among many others) discover that eating a 10 week diet high in fermented foods such as kimchi, fermented cabbage (sa uerkraut) or cucumbers boosts the diversity of gut microbes, and improves immune responses. ( Read more below ) SCOBY (Symbiotic Culture Of Bacteria and Yeast) based kombucha and jun tea, or KEFIR MILK . Go with the one you like the most and make it part of your daily diet. ( Read more below ) Your keto diet with Soluble and insoluble fiber intake: vegetables, nuts, and seeds, including sprouted seeds. Avoid: Antibiotics , unless absolutely necessary (and when you do, make sure to replenish your gut with fermented foods and/or a probiotic supplement. Conventionally-raised meats and other animal products, as CAFO animals are routinely fed low-dose antibiotics, plus genetically engineered grains loaded with glyphosate, which is widely known to kill many bacteria Chlorinated and/or fluoridated water . Processed foods . Excessive sugars, Food emulsifiers such as polysorbate, lecithin, carrageenan, polyglycerols, and xanthan gum also appear to have an adverse effect on your gut flora. Read more Scoby Benefits SCOBY Derivatives Benefits This study concludes : "Kombucha has broad microbial diversity enriched with organic acid producing microorganisms, laying the groundwork for immense potential for health benefits ". Candida fighters : SCOBY derivatives have an abundance of beneficial bacteria - Probiotics yeast strains that compete with Candida yeasts. (Read more ) Probiotics provide your gut with healthy bacteria. These bacteria can improve many aspects of health, including digestion, inflammation and even weight loss. With compounds such as glucuronic acid exerting their positive qualities, they help fight off adverse yeast infections by promoting a healthier microflora environment. (read more ). Liver Cleansing : When brewed, SCOBY derivatives produce organic acids like vinegar which are sour and bitter, contributing to the health of our liver by stimulating enzymes and Bile production, essential for natural detox and cleansing by the liver. Heart Disease : Rat studies show that SCOBY derivatives can greatly improve two markers of heart disease, “bad” LDL and “good” HDL cholesterol, in as few as 30 days (Read more ). 1.0 2 Ratings average rating is 1 out of 5, based on 2 votes, Ratings Reviews Scoby HomeMaking Antibiotics and Our Microbiome Brain Function : SCOBY Contains vitamins B1, B2, B3, B6, and B12, which contribute to energy production and brain function. Cell repairment : SCOBY Contains many amino acids which are the compounds of proteins needed for the repair of our cells. ( Read more ) Other Benefits : Polyphenols in the SCOBY derivatives contain antioxid beneficial bacteria and yeast strains that are a by-product of the fermentation of the sugar, and these feed our good gut bacteria and contribute to good mental health, immune health, and a healthy weight.ants that stop our DNA from being damaged by external and internal pollutants, contributing to the process of disease. ( Read more ) Additional Benefits: contribute to good mental health, immune health, and a healthy weight. Detox : SCOBY derivatives are rich in enzymes and bacterial acids that occur naturally in our bodies for detoxing our systems; Rat studies consistently find that drinking SCOBY derivatives regularly reduces liver toxicity caused by toxic chemicals, in some cases by at least 70% ( Read more ). Anti Cancer: SCOBY derivatives contain gluconic acid, shown by recent studies to help prevent cancer. ( Rea d more ). Home making of SCOBY based "drinks" There are numerous recipes on the web for scoby drinks of various tastes. We strongly recommend to start with the basic ones and "expand" the list if you feel that the basic is not enough. We found, using our own experience, that the two links included here could be a good start: Basic Jun recipe, Basic Kombucha recipe (and where to source Jun and Kombucha kitchen accessories, and materials).Also, you may find a great variety of recipes in the book of Julia Mueller: Delicious Probiotic Drinks Home making of KEFIR Milk "drinks" Yet another good source for a Kefir Milk recipe (as well as many other recipes) could be found at this link. Additional diet change actions The reduced diversity of the gut microbiota in Western populations compared to that in populations living traditional lifestyles is a good starting point to answer the question of which factors have driven microbiota change during modernization. Microbiota-accessible carbohydrates (MACs) found in dietary fibre have a crucial involvement in shaping this microbial ecosystem, and are notably reduced in the Western diet (high in fat and simple carbohydrates, low in fibre). Read more: Erica Sonnenburg et.al. Antibiotics and Our Microbiome Numerous scientific articles and the National Institutes of Heal th agree to this concise summery : "The human gastrointestinal tract carries a large number of microorganisms associated with complex metabolic processes and interactions. Although antibiotic treatment is crucial for combating infections, its negative effects on the intestinal microbiota and host immunity have been shown to be of the utmost importance. Multiple studies have recognized the adverse consequences of antibiotic use upon the gut microbiome in adults and neonates, causing dysbiosis of the microbiota". Home Making of Kefir Milk Role of Gluten and Sugar ADDITIONAL DIET CHANGE ACTIONS The reduced diversity of the gut microbiota in Western populations compared to that in populations living traditional lifestyles is a good starting point to answer the question of which factors have driven microbiota change during modernization. Microbiota-accessible carbohydrates (MACs) found in dietary fibre have a crucial involvement in shaping this microbial ecosystem, and are notably reduced in the Western diet (high in fat and simple carbohydrates, low in fibre). Read more: Erica Sonnenburg et.al. The role of Gluten and Sugar! Gluten: Certain features of gluten make it more likely to impair immune responses than other proteins. One key difference is that gluten is less amenable to being broken down by the enzymes that normally digest proteins. Another factor is gluten’s propensity to bind to certain proteins in immune cells that normally detect pathogens (damaging external factors). This leads to a cascade of events that result in the activation of various types of immune cells; in other words, gluten causes inflammation. Read more about gluten Sugar: Diets high in sugar increase chronic inflammation . Sugar contributes to the formation of harmful biochemical compounds that spike inflammation. Sugar and refined carbohydrates cause unhealthful, inflammation-boosting changes to gut bacteria. Read more about sugar . Fresh Vegetables Fresh vegetables are essential. You can find detailed information about nine foods for brainpower here . For instance, curry, celery, broccoli , cauliflower, and walnuts contain antioxidants and other compounds that protect your brain health and may even stimulate the production of new brain cells. Omega-3 Very important! Increase your Omega-3 fat intake and reduce consumption of damaging omega-6 fats (think processed vegetable oils) to improve the ratio of your omega-3 to omega-6. There are some that prefer krill oil to fish oil, as krill oil also contains astaxanthin , which not only protects the omega-3 fats from oxidation but also is particularly important in supporting brain health. Coconut oil is another healthful fat for brain function. This study has shown the positive effect of medium-chain triglycerides (MCT) daily intake of 42 grams on Alzheimer's disease patients which indicates that MCT oils rich (coconut oil) could have the effect of either a preventative measure against degenerative neurological diseases or as a treatment for an already established case. Additional Diet Change Actions Fresh vegetables Omega-3

Acupuncture and Acupressure Back to Brain Solution: Acupuncture for Dementia – How does the Treatment Help? Acupuncture provides a large range of effects, which include the systematic reduction of inflammation and promotion of circulation, among other things. Though it is still not clear exactly how acupuncture initiates the healing process, most patients hardly care as they are just happy over the fact that the treatment is working. Several types of research conducted in the Beijing Hospital of Traditional Chinese Medicine and the Beijing University of Chinese Medicine have shown that through great many tests such as the Morris water maze for detecting the neuroprotective effects and detecting levels of DNA oxidation for the oxidative stress aspects, researchers wanted to find out whether acupuncture could mimic a similar effect of TXNIP inhibition. Now, what is TXNIP? TXNIP, more elaborately known as Thioredoxin-interacting protein, is in plain terms a kind of switch which sets the ball rolling for the destructive processes present in vascular dementia along with conditions such as diabetic neuropathy, for example. So in layman’s terms, if we are able to inhibit the release of TXNIP, it will also inhibit the types of damage that lead to a range of issues. The study revealed several important points about acupuncture and how it was able to reverse a number of negative inflammatory and destructive markers which include TXNIP. Acupuncture is more effective in dealing with and treating dementia than conventional drug therapy, this has been backed by researchers at the Wuhan University of Science and Technology. It was published in the Journal of the Hubei University of Chinese Medicine. Their research has clearly demonstrated that acupuncture can be both a safe and effective treatment for vascular dementia. Acupuncture has achieved an impressive 90% total efficacy rate, especially when you use the Xing Nao Kai Qiao acupuncture protocol, closely followed by conventional acupuncture which managed to notch up an 80% total efficacy rate, further followed by drug therapy which fetched up a 60% total efficacy rate. It is recommended that you contact a practitioner for this therapy proce dure. Customer Reviews QUESTIONS ASKED Please try to present your review by responding to the questions below. We try to make your review as clear and brief as possible, to make it easy for other members to learn from your experience. 1. Describe the pain/problem 2. What was the Dosage (concentration, number of "takes" per day...) 3. Describe How did you apply it (swashing, swallow, skin surface spread... 4. How long did it take to notice improvement (time to start getting results....) 5. What is the final outcome 6. More info that you want to share Reviews (ratings are between 1 to 10) Reviews: .. Display reviews by rating: select the rating, and then click the button ≥ or ≤ ≥ ≤ Load More Reviews Write your Review 1) Describe the pain/problem that you wanted a solution for: 2) What was the Dosage (concentration, number of "takes" per day...) 3) Describe How did you apply it (swashing, swallow, skin surface spread... 4) How long did it take to notice improvement (time to start getting results....) 5) What is the final outcome 6) More info that you want to share 7) Please select your final grade to this solution between 1 to 10: Submit Your content has been submitted An error occurred. Try again later

Oregano oil and its carvacrol theraputic power as the most effective infection and inflamation depresent. How the right diet, reinforced with vitamins D and C (not ascorbic acid!) can subdue infection and inflamation. AGE RELATED HEALTH ISSUES Page Content: Background Telomeres Attrition Risk Factors of Disregulation of Immune System The key factor in chronic inflammation Coping with chronic inflammation Health Issues Caused By Impaired Nitric Oxide Generation Nitric Oxide Enrichment Age Related ATP Production Decline Nicotinamide Adenine Dinucleotide (NAD+) Depletion Arthritis Related Linked Pages: BPH Diabetes Stroke Age Related Skin Issues Background The aging process involves many body functioning factors. On this page we present some of the leading factors of this process and its health implications: At the Cell Level Telomeres attrition , characterized by the shortening of telomeres with each cell division, paradoxically serves as both a protective mechanism and a contributor to tissue degeneration and age-related ailments. Tissue (metochondria) ATP production decline, Body Health Dysregulation of the immune system that leads to a chronic systemic inflammatory state, Nitric Oxide impaired generation and signaling that contribute substantially to cardiovascular risk and associated health issues, Parasites/pathogen proliferation Background TELOMERES ATTRITION T elomeres attrition - When telomeres shorten beyond a certain threshold, the cell ends its functional life and in the best case dies, or in the worst case, gets stuck in a state that can be called a "zombie cell" (Senescent cell), which is a harmful state because these cells continuously transmit inflammatory distress signals, increase inflammation In general, and in general, the accumulation of such zombie cells is considered one of the characteristics and drivers of aging and morbidity. Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. This recent study published in Nature showed that Gut-specific telomerase enzyme expression counteracts systemic aging, or in other words if we slow down the aging of the intestinal cells, it slows down the aging of the entire being!!! Increasing Telomarse Enzyme Levels Follow a plant-rich diet high in fruits, vegetables, nuts, and whole grains[ 1 ][ 2 ]. This type of diet is associated with longer telomeres and increased telomerase activity. Exercise regularly, aiming for at least 30 minutes of moderate physical activity 6 days a week[ 3 ][ 5 ]. Regular exercise has been shown to increase telomerase activity and reduce telomere shortening. Manage stress through practices like gentle yoga, breathing exercises, and meditation[ 3 ]. Stress reduction techniques can help maintain telomere length and potentially increase telomerase activity. Ensure adequate intake of folate from natural sources rather than synthetic folic acid[ 2 ]. Folate-rich foods contribute to DNA synthesis and repair, which may benefit telomere health. Supplement with vitamin D , as higher levels are associated with longer telomeres[ 2 ]. A daily dose of 800 IU has shown promising results in improving telomere length. Consume foods rich in antioxidants and omega-3 fatty acids , such as fish, flax seeds, and leafy greens[ 1 ][ 4 ]. These nutrients help combat oxidative stress and inflammation, which can protect telomeres. Include specific nutrients that may activate telomerase, such as astragalus root extract, milk thistle seed extract, Korean ginseng extract, and L-citrulline[ 1 ]. Maintain a healthy weight and avoid smoking and excessive alcohol consumption[ 4 ]. Obesity and unhealthy habits can increase oxidative stress and accelerate telomere shortening. Telomeres Attrition Risk Factors of Disregulation of Immune System RISK FACTORS FOR DYSREGULATION OF IMMUNE SYSTEM THAT LEADS TO CHRONIC INFLAMMATION " Supporting energy production and reducing inflammation in the brain are the two most important factors to prevent and treat Alzheimer". For energy production - Read more here about our recommended diet. " One of the major changes that occur during aging is the dysregulation of the immune response, leading to a chronic systemic inflammatory state." How does systemic chronic inflammation (SCI) - impact the body ? There are multi-level mechanisms underlying SCI and several RISK FACTORS that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. First and foremost, try to reduce (preferably - eliminate) these risk factors! (Read more ) Chronic inflammation can start damaging healthy cells, tissues, and organs. Over time, this can lead to DNA damage, tissue death, and internal scarring. One of the most important medical discoveries of the past two decades has been that the immune system and inflammatory processes are involved in not just a few select disorders, but a wide variety of mental and physical health problems that dominate present-day morbidity and mortality worldwide. Indeed, chronic inflammatory diseases have been recognized as the most significant cause of death in the world today, with more than 50% of all deaths being attributable to inflammation-related diseases such as ischemic heart disease, stroke, cancer, diabetes mellitus (diabetes type 2 ), chronic kidney disease, non-alcoholic fatty liver disease (NAFLD) and autoimmune and neurodegenerative conditions. (Read m ore ) A key factor in chronic inflammations Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging. This reshaping of cytokine expression pattern, with a progressive tendency toward a pro-inflammatory phenotype has been called “inflamm-aging.” Despite research there is no clear understanding about the causes of “inflamm-aging” that underpin most major age-related diseases, including atherosclerosis, diabetes, Alzheimer’s disease, rheumatoid arthritis, cancer, and aging itself. “The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear”.(Read more ) COOPING WITH CHRONIC INFLAMMATION First and foremost , start the keto diet, take care of your microbiome, and exercise (Read more on this page ). Note, there is a "UNANIMOUS" AGREEMENT among practitioners and "experts" that diet is the underlying cause for chronic inflammation, and therefore a diet change is the first and most important element in the recovery process. Give up smoking, keep healthy weight and exercise and your health restoration will follow! 4.8 8 Ratings average rating is 4.8 out of 5, based on 8 votes, Ratings Reviews Key Factors in Chronic Inflammation Cooping with Chronic Inflammation Health Issues from Impaired Nitric Oxide Generation HEALTH ISSUES CAUSED BY IMPAIRED NITRIC OXIDE GENERATION AND SIGNALING AGE RELATED NITRIC OXIDE EFFECTS The three long quotations below highlight the significant role of nitric oxide in age related decline and disease. "Twenty percent of the Medicare population has at least five chronic conditions i.e., hypertension, diabetes, arthritis, etc. Studies in experimental models and even humans reveal that constitutive production of nitric oxide (NO) is reduced with aging and this circumstance may be relevant to a number of diseases that plague the aging population. NO is a multifunctional signaling molecule, intricately involved with maintaining a host of physiological processes including, but not limited to, host defense, neuronal communication and the regulation of vascular tone. NO is one of the most important signaling molecules in our body, and loss of NO function is one of the earliest indicators or markers of disease." "Impaired generation and signaling of nitric oxide contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent CVR factor. Many processes involved in aging are modulated by NO. We therefore postulated that aging might be independently associated with impaired NO signaling." "Aging is associated with a decline in physiological function and exercise performance. These effects are mediated, at least in part, by an age-related decrease in the bioavailability of nitric oxide (NO), a ubiquitous gasotransmitter and regulator of myriad physiological processes. The decrease in NO bioavailability with aging is especially apparent in sedentary individuals, whereas older, physically active individuals maintain higher levels of NO with advancing age. Nitric oxide (NO) is a gaseous signaling molecule that plays an essential role in regulating systemic physiological function. As such, maintaining NO homeostasis is essential for optimal function and health [1 ], [2 ], [3 ]" Nitric Oxide Enrichment The process of maintaining NO homeostasis is quite complex but there are strong evidences about the role of flavonoids in Modulating this process . Furthermore, research work on the exceptional health and life expectancy of the Kuna tribe has linked it to their exceptional flavonoids rich cocoa consumption.[4 ], [5 ], [6 ] Nitric Oxide Enrichment Practice Do not confuse this compound - Nitric Oxide - (NO), with nitrous oxide with the chemical formula N2 O which is a powerful oxidiser. "One of the main mechanisms by which dietary flavonoids are thought to influence cardiovascular disease is via protection of the bioactivity of the endothelium-derived nitric oxide (NO) ."[REF1 ]. "The endothelium plays an important role in the maintenance of vascular homeostasis. Central to this role is the endothelial production of nitric oxide (NO) , synthesized by the constitutively expressed endothelial isoform of nitric oxide synthase" [REF2 ] Authentic cocoa and coffee powders are rich with flavonoids. A 5 grams of cocoa (a table spoon) contains up to 130 mg of flavonoids . This study brings a lengthy discussion about the preferred flavonoids daily dosage, but as with many others dealing with this specific issue (flavonoids daily dosage), it does not provide a simple answer. So what left for us is to recommend that you try to follow the Kuna indigenous tribe members and drink as much unsweetened cocoa as you feel good with (they drink 10 ounces of water with cocoa a day). What we do is adding a spoonful of cocoa powder to our coffee - you are welcome to try it. Alternatively, you may want to follow Dr. Gundry's recommendations or anybody else that you consider as a trust worthy one. 5.0 1 Ratings average rating is 5 out of 5, based on 1 votes, Ratings Reviews Nitric Oxide Enrichment Practice Citrus Peels "It has been found that peels are the main sources of polyphenols in citrus fruits [6 ]. Peel residues from sweet and bitter oranges, lemons, and mandarins have proved to be an important source of phenolic acids and flavonoids, chiefly polymethoxyflavones (PMFs), flavanones, and glycosylated flavanones [7 –10 ]. These bioactive compounds are strongly associated with therapeutic properties including antiallergenic, antiatherogenic, anti-inflammatory, antimicrobial, anticarcinogenic, antithrombotic, cardioprotective, and vasodilatory effects [11 –18 ]". Ceylon Cinnamon Bark Oil Anti Aging Properties There are many supplements that have one anti aging property or another. What sets the cinnamon oil apart is the broad spectrum of its anti aging benefits, and the fact that it is a tasty supplement, making it easy to add as a daily supplement, without the need to ingest it in a capsule. This study " Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review " presents the results of 70 studies (published before Dec. 2012) on the "subject": "The beneficial health effects of Cinnamomum Zeylanicum identified were; a) anti-microbial and anti-parasitic activity, b) lowering of blood glucose, blood pressure and serum cholesterol, c) anti-oxidant and free-radical scavenging properties, d) inhibition of tau aggregation and filament formation (hallmarks of Alzheimer’s disease), e) inhibitory effects on osteoclastogenesis, f) anti-secretagogue and anti-gastric ulcer effects, g) anti-nociceptive and anti-inflammatory activity, h) wound healing properties and i) hepato-protective effects. The studies reported minimal toxic and adverse effects." Talking of aging, this study that focuses on "The breakdown of collagenous networks with aging results in hypoactive changes in the skin." concludes : "Cinnamon extract potently up-regulated both mRNA and protein expression levels of type I collagen without cytotoxicity. We identified cinnamaldehyde as a major active component promoting the expression of collagen by HPLC and NMR analysis." or to put it simply: "These results suggested that cinnamon extract is useful in antiaging treatment of skin. " Dosage: daily dosage should be 3-5 drops of oil diluted in 1/2 table spoon of coconut oil . Read on this page about how to select a good quality cinnamon oil. 5.0 2 Ratings average rating is 5 out of 5, based on 2 votes, Ratings Reviews 3.5 2 Ratings average rating is 3.5 out of 5, based on 2 votes, Ratings Reviews Age Related ATP Production Decline AGE RELATED TISSUE (METOCHONDRIA) ATP PRODUCTION DECLINE Triggers for Decline in Tissue ATP Production Decline with Age The decline in tissue ATP production with age is triggered by several interconnected factors: Mitochondrial Dysfunction As we age, mitochondrial function declines significantly, leading to reduced ATP production: There is a decrease in mitochondrial respiration and ATP production with increasing donor age, approximately 10% per decade[1 ]. Aging is associated with accumulation of mitochondrial DNA damage and mutations, impairing the electron transport chain and reducing ATP generation. Mitochondrial dysfunction leads to increased production of reactive oxygen species (ROS), further damaging mitochondria in a vicious cycle[4 ]. Oxidative Stress Increased oxidative stress with age negatively impacts ATP production: Higher levels of ROS damage cellular components including proteins, lipids and DNA[4 ]. Oxidative damage to mitochondrial proteins and DNA impairs their function and ATP generation capacity. Age-related decline in antioxidant defenses leaves cells more vulnerable to oxidative damage[5 ]. Hormonal Changes Alterations in hormone levels with age affect energy metabolism: Decreased growth hormone levels reduce mitochondrial function and ATP production[2 ]. Increased insulin resistance impairs glucose uptake and utilization for energy production. Reduced Physical Activity Declining physical activity with age contributes to reduced ATP production: Lack of exercise leads to decreased mitochondrial content and function in muscles[2 ]. Physical inactivity results in muscle atrophy and reduced capacity for ATP generation. Nicotinamide Adenine Dinucleotide (NAD+) Depletion NAD+ depletion refers to its reduction levels in cells and tissues. This is a significant issue that occurs with aging and in various pathological conditions. NAD+ is a critical molecule , essential for creating cellular energy and maintaining cellular health. Levels of this critical molecule correlate with health status in aging. Age-related decline in NAD+ levels impairs energy metabolism: NAD+ is essential for mitochondrial function and ATP production through the electron transport chain[1 ]. Decreased NAD+ impairs mitochondrial quality control mechanisms like mitophagy (a type of selective autophagy through which damaged mitochondria are marked and recognized by the cellular autophagic machinery[2 ]). Here are the key points about NAD+ depletion: Aging: NAD+ levels naturally decline with age, approximately 10% per decade after adulthood[3 ]. Increased NAD+ consumption: Enzymes like PARPs, CD38, and sirtuins consume NAD+ at higher rates during stress, DNA damage repair, and inflammation[4 ][5 ]. Reduced NAD+ synthesis: The activity of key NAD+ biosynthesis enzymes like NAMPT decreases with age[4 ][5 ]. Metabolic dysfunction: Conditions like obesity and diabetes can accelerate NAD+ depletion[5 ]. In summary, mitochondrial dysfunction, oxidative damage, hormonal changes, physical inactivity, and NAD+ depletion work together to trigger the decline in tissue ATP production observed with advancing age. This creates a self-reinforcing cycle, as reduced ATP further exacerbates these underlying factors. Nicotinamide Adenine Dinucleotide (NAD+) Depletion

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