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NICOTINE Page Content: About Nicotine Nicotine and Brain Functioning Nicotine Anti-Inflammatory Benefits Nicotine-Mediated Cell Proliferation Ischemic Injury Parkinson’s Disease Nicotine is a naturally occurring alkaloid primarily found in the tobacco plant, where it constitutes about 5% of the plant's weight. It can also be found in smaller amounts in other plants of the nightshade family. About Nicotine As described below, Nicotine benefits to many body functions, most notably brain functions - are far reaching with no side effects, AND NO ADDICTIVENESS (As proven by this recent Harvard Study ) if taken appropriately. Nicotine and Brain Functioning Nicotine administration can improve cognitive decline and impairment by inhibiting Sirtuin 6, a stress‑responsive protein deacetylase, thereby decreasing neuronal apoptosis and improving neuronal survival, a quality which is most important in Alzheimer's disease (AD), memory impairment in Parkinson's disease (PD, Read more below ) and dyskinesia (Read More , And more ). Nicotine improves cognitive impairment by enhancing protein kinase B (also referred to as Akt) activity and stimulating phosphoinositide 3‑kinase/Akt signaling, which regulates learning and memory processes. Nicotine may also activate thyroid receptor signaling pathways to improve memory impairment caused by hypothyroidism. In healthy individuals , nicotine may improve memory function through its effect on chromatin modification via the inhibition of histone deacetylases, which causes transcriptional changes in memory‑related genes. Furthermore, nicotine improves memory impairment caused by sleep deprivation by enhancing the phosphorylation of calmodulin‑dependent protein kinase II, an essential regulator of cell proliferation and synaptic plasticity. Finally, nicotine administration has been demonstrated to rescue long‑term potentiation in individuals with sleep deprivation, AD, stress and hypothyroidism, primarily by desensitizing α7 nicotinic acetylcholine receptors. To conclude, nicotine has several cognitive benefits in healthy individuals, as well as in those with cognitive decline associated with age or brain deseases. chronic Nicotine Anti-Inflammatory Benefits Inflammation is a complex process involving multiple genes and signaling pathways. In the recent decade, the finding that pro-inflammatory responses are controlled by neural circuits has given birth to the new concept of “inflammatory reflex. The cholinergic anti-inflammatory pathway is the efferent or motor arm of the “inflammatory reflex”, the neural circuit that responds to and regulates the inflammatory response. It is well known that nicotine, as an agonist of nicotinic Acetylcholine Receptors (nAChR) found in the central and peripheral nervous system, muscle, and many other tissues of many organisms, stimulates the nicotinic acetylcholine receptor signaling anti-inflammatory pathway to reduce inflammatory responses. (Read more) Nicotine is a lipophilic agent and can penetrate the cells independently on these special nAChR receptors. Therefore, nicotine could directly affect mitochondrial respiration , cell autophagy, and cell signaling molecules in an environment with proper pH (nicotine pKa = 7.9). Yet another study showed that given at the right dose, nicotine provides for a "protective effect of nicotine in a murine model of viral myocarditis induced by coxsackievirus". B3Nicotine also played different regulatory roles in ulcerative colitis, arthritis, periodontitis, sepsis, endotoxemia, multiple sclerosis, nasal eosinophilic inflammation, allergy, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, skin inflammation, placental inflammation, pancreatitis, Behçet’s disease, muscle inflammation, viral myocarditis, uveitis, experimental autoimmune encephalomyelitis, systemic lupus erythematosus, and so on (Figure 1 ) Nicotine and Brain Functioning Anti-Inflammatory Benefits Nicotine-Mediated Cell Proliferation and the Formation of New Blood vessels (Angiogenesis). Nicotinic acetylcholine receptors (nAChRs) that are widely distributed in the brain and neuromuscular junctions, were found to be expressed in a variety of non-neuronal tissues in the body including those of the lung . Recent studies show that these non-neuronal nAChRs can induce cell proliferation and angiogenesis. Angiogenesis involves the migration, growth, and differentiation of endothelial cells, which line the inside wall of blood vessels, controlled by chemical signals in the body. Angiogenesis is critical for wound healing and tissue repair, enabling the formation of new blood vessels to support the regeneration of damaged tissues. Ischemic Injury Ischemic injury is a pathological condition that occurs when the blood supply to organs and tissues is temporarily restricted or cut off, depriving them of nutrients, oxygen, and sugar. Recent studies have shown that cerebral hypoxia-ischemia causes neural inflammation, which eventually results in neuronal cell death. Nicotine inhibits microglial proliferation and is neuroprotective in global ischemia. Parkinson’s Disease Preliminary analysis shows improvements after acute nicotine in several areas of cognitive performance, particularly measures such as reaction time, central processing speed, and decreased tracking error. Nicotine-Mediated Cell Proliferation Ischemic Injury Parkinson"s Disease

Origanum Minutiflorum Wild Harvasted Oregano Oil Page Content: 1. Quality Issues 2, Special Qualities to Look for 3. Health Benefits 4. Usage and safety 100% PURE, WILD, ORGANIC, ORIGANUM MINUTIFLORUM OIL, 1 fl oz (30 ml) Product details Highly concentrated, above 75% Carvacrol, No thymol content, No standardization, no additives, Steam distilled premium quality essential oil, Suitable for internal consumption with medical supervision & advice QUALITY ISSUES QUALITY ISSUES Why Origanum Minutiflorum? How could you tell that your oregano vulgar is "WILD HARVESTED"? Origanum Minutiflorum is “rare and grows only at altitudes above 1500 m, on rocky soils, and on only two or three mountain massifs in southern Turkey”[RE F ]. In other words - it can only thrive, when growing wild at high altitude.This harvesting source ensures natural, high level, relatively homogeneous, carvacrol as well as other important ingredients. Read more OREGANO VULGAR "WEAKNESSES" The most common plant used for oregano oils - Oregano Vulgar , is cultivated throughout the world at low altitudes with many subspecies. As such, many vendors of this product, tend to STANDARDIZE, the extracted oil, namely adding to the oil one or more ingredients - most notably, adding carvacrol, to maintain a "good level" of that ingredient. Some vendors will claim for "Wild oregano plant harvested from high altitude habitat" with no attempt to substantiate this claim. Using the Origanum Minutiflorum resolves the substantiation issue because it is not cultivated, and its wild habitat is very limited to the Massifs Mountains in southern Turkey. [RE F ] NOTE! Many oregano oil vendors became aware of the ORIGANUM MINOTIFLORUM superior qualities and are naming there oregano oil as origanum minutiflorum, without actually sourcing their oil or the leaves they use for the extraction of the oil from that plant. If you want this unique oil, verify its source and don't let the product name to mislead you. OREGANO OIL BLENDS - Some oregano oil vendors do not make it very clear that their product is a blend (most often with olive oil) where the olive oil is the major ingredient in the bottle. Some of these vendors offer a "regular" oregano oil (the word blend is not mentioned) and a super strength oregano oil which according to one of their sellers "...the difference between super strength and regular strength is that the ratio of olive oil to oregano oil is considerably different, by nearly 3-fold." They would tell you that the carvacrol content in their oregano oil is above a certain percentage, but without knowing the composition of the blend that they offer in the bottle, you would not be able to figure out, how much carvacrol you really get in the oil that you take! Of coarse, pure oregano essential oil should be blended significantly before use (between 1-4 drops in a tablespoon of a carrier oil - like olive oil, read more below ), be it for topical or ingestion, but most customers are not aware that what they buy is not the pure oregano oil but mostly an olive oil! STANDARDIZATION of essential oils alters and disrupts their natural construction. Standardization practice intends to maintain consistency and/or to selectively increase specific naturally occurring compounds - most notably, carvacrol. This can be done by the producer, before, during or after the extraction process. Examples of standardization practices include modifications of the plant seed and growth environment, and the addition of isolated components post-distillation/extraction. This selective process disrupts the synergy that occurs when trace components that would otherwise naturally occur within the plant are lost to make room for the unnatural increase in components. As demonstrated by this study [REF ], the overall effect of the beneficial components Disruption of this synergy, has a dramatic impact of lowering the effectiveness of the oil. Regardless of the technique, when the natural composition of the oil is altered, and synergy is compromised, renders the oil to become less effective than if it were in its natural state. We recommend 100% pure origanum minutiflorum oil which needs no standardization or any other practice to improve its quality from the harvesting of the wild plant through the distillation process, preservation of its natural qualities is the guiding line. Coordinated with regional forestry authorities, the origanum we recommend is carefully harvested, to preserve this specie in this unique habitat. Special qualties to look after SPECIAL QUALITIES TO LOOK FOR On this page of this website we present many scientific references that confirm the superior effectiveness of the oregano oil and its various ingredients - most notably carvacrol and thymol, to combat various infections and inflammation that may inflict our body. In the section below, we provide details of specific health conditions and references to scientific studies that demonstrated the benefits of oregano oil in coping with these conditions. We recommend this product because of its importance as a herbal treatment for health issues and the fact that very few out of its numerous providers bother to mention the exact plant variety that they use, its harvesting grounds and the significance of these elements on the quality of its health ingredients. Offerings that provide information on the source of their oregano oils are expensive. Here we try to call your attention beyond the oil's price, to the details of its source and the content level of its important ingredients. Health benefits OREGANO OIL HEALTH BENEFITS - SCIENTIFIC EVIDENCES NOTICE, IN THIS SECTION WE PROVIDE LINKS TO SOME OF THE HEALTH CONDITIONS THAT ARE DETAILED ON OTHER PAGES OF THIS WEBSITE, WHERE ADDITIONAL BENEFICIAL OPTIONS ARE PRESCRIBED. FLU, COLDS , RESPIRATORY INFECTIONS , SORE THROAT , COUGHS All these conditions are categorized under "viral infection". As demonstrated on this page , scientific studies (e.g. [REF ]) demonstrated the efficacy and mechanisms of action of oregano essential oil and its primary component carvacrol against a wide range of pathogens. INFLAMMATION OF THE SMALL INTESTINE AND INTESTINAL PARASITES There are many factors that contribute to gut inflammation, including diet and lifestyle habits, microbial balance and the presence of toxins. The truth is, that many people have intestinal parasites and don’t even know it! They are not uncommon, and oregano oil can help to rid them from your body. [REF ] This referenced study [REF ], has shown a reduction in inflammation throughout the small intestine and colon, with pigs fed with oregano essential oil. “A potential factor of gastrointestinal dysfunction and pathology, including Crohn's disease, multiple organ dysfunction, bacterial translocation, food allergies, and acute pancreatitis”. BACTERIAL VAGINOSIS (BV) a disease of the vagina caused by excessive growth of bacteria. Common symptoms include increased vaginal discharge that often smells like fish. The discharge is usually white or gray in color. Burning with urination may occur. Usually, "good" bacteria (lactobacilli) outnumber "bad" bacteria (anaerobes) in your vagina. But if anaerobic bacteria become too numerous, they upset the natural balance of microorganisms in the vagina and lactobacilli decrease. As we already presented on this page oregano is a well-studied natural antimicrobial that can be utilized to rid the body of excess bacterial and fungal overgrowth. RECOMMENDED PRACTICE If symptom observed - properly dilute 3-5 drops of oregano oil into carrier oil of choice, take 3x daily for 4-5 days. Preventative - properly dilute 3-5 drops of oregano oil into carrier oil of choice, take once daily or every other day. Usage and safety OREGANO OIL USAGE AND SAFETY Usage This highly concentrated oil is best for the various health conditions as described above. As with all other essential oils, DO NOT use the oregano oil without dilution in a carrier oil! To avoid irritation of skin or mucous membrane (lips for example), There's no standard effective dose of oregano essential oil as herbal supplement. Some recommend [REF ] to make a mix of around 1 teaspoon (5 mL) of coconut oil (most recommended) or olive oil per a drop of oregano essential oil when applied directly to the skin. For ingestion use, 1 - 4 Drops per tablespoon (one tablespoon = 15 ml) of a carrier oil (such as coconut or olive oils) would provide the appropriate dilution. A 10 ml glass Measuring Dropping Pipette (with a Rubber Head) is a good kitchen aid to prepare the right mixture of a carrier oil with an essential oil for repeated usage. In case that you want to use a teaspoon, its volume is around 5 ml. NOTICE! Once you have the diluted mixture ready, take a teaspoon of the mixture once or twice a day. If you feel some burning/stinging feeling on your lips (that touched the teaspoon) and palate, take a tablespoon, deep it in your coconut oil and lick and swallow the oil. You will notice that the annoying feeling is gone away in seconds. Notice, a dropper oil drop is about 0.05 milliliter (ml), and a teaspoon is about 5 ml so that 1 - 4 drops per tablespoon translates to a recommended concentration of ~0.75% - 2% of the oregano essential oil in the carrier oil. We provide the table below for those who want to prepare larger volumes of oil ready for consumption. It is recommended to consult with your physician for edible consumption, Do not use it if pregnant or near children under 2 years of age. Keep out of reach of children. Some people may be allergic to Cinnamon Oils. Safety Information Oregano essential oil, is relatively non-toxic. Its major ingredient - carvacrol (above 75%) could be irritating to the mucous membranes (i.e. lips): so use in moderation, always dilute it with a carrier oil (such as coconut or olive oil) as recommended above. The oil should be used carefully when applied to the skin, causing irritation, reddening, and even a burn to sensitive skin. Therefore, use carefully. Read about the properties and usage of essential oils. Consult with a knowledgeable source for indications and contraindications before use. Keep out of the reach of children. Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Heart health and the contribution of the microbiome and diet to its maintanence. Info on heart health with respect to collesterol and statins. Risky Foods Page Content: Food Contaminates Chemical Contaminates Our Exposure to Environmental Chemicals The Real Danger to Health The Build-up of Toxins Certified "ORGANIC" Foods and Heavy Metals Body Interaction with Heavy Metals Transgenerational Toxicity Transfer Related Linked Pages: Rice and Arsenic Glyphosate Back to Prevention Lectin, Gluten, Phytic Acid, Emulsifiers Chemical Contaminates Food Contaminates The Build-up of Toxins The Real Danger to Health Our Exposure to Environmental Chemicals Chemical Contaminates Poisonous forms of toxic compounds - pesticides, insecticides, herbicides, and heavy metals like mercury, lead, cadmium, arsenic, aluminum, copper, tin, tungsten, chromium, beryllium, and other elements are increasingly found in our post-industrial environment. As industry expanded in the nineteenth and twentieth centuries, toxic heavy metals were mined, smelted, and added to any number of products that released those metals directly into the environment. Leaded gasoline, for example, released lead directly into the air with every stroke of the combustion engine. Mercury fillings resulted in thousands of tons of mercury being expelled into the atmosphere as the bodies of those who passed away were cremated. Lead arsenate was also widely used as a pesticide on orchards and food crops across North America for much of the nineteenth century. Once expelled into the open environment, heavy metals may be inhaled, ingested, or absorbed into humans, animals, plants, and fungi, or they may be transformed and combined with other substances to create new compounds but they cannot simply vanish. They persist. It is the industrial exploitation and expelling of these elements—which were originally sparse and spread out at relatively low levels—that has turned vague primordial threats into everyday dangers. As by-products of smelting, ore extraction, energy production, and commercial goods, heavy metals and refined chemical compounds have poured into our air, water, soils, foods, ecosystems, and bodies. Our Exposure to Environmental Chemicals In September 2013, the CDC issued its updated fourt h National Report on Human Exposure to Environmental Chemicals, detailing more than 201 chemical substances that have been identified in blood serum and urine levels throughout the U.S. population. These can be ingested, absorbed, stored, excreted, metabolized, or bound to other compounds, potentially interacting with, blocking, or amplifying reactions within the body. While many elements, including trace levels of certain minerals, are essential nutrients for catalytic conversions and biological functions, alarming concentrations of toxic forms of these elements have found their way into our lives at a pace that’s wildly out of balance with nature and hazardous to our health and longevity. The Real Danger to Health The real danger to health comes from long-term exposure to low-level doses of toxins over time, including heavy metals. A few dozen key contaminants may be taking a crucial but yet uncalculated toll on the well-being of everyone around the world - with increased levels of toxins in everyday foods contributing to a general rise in inflammation, immunological and digestive disorders, neurological damage, organ failure, heart and lung ailments, cancer, and other serious diseases and conditions. The Build-up of Toxins Science now recognizes that these detrimental health effects are triggered by gradually accumulating, minuscule concentrations of toxins through repeated dietary or environmental exposure. The tidal wash of pesticides, herbicides, insecticides, fungicides, rodenticides, fertilizers, preservatives, emulsifiers, and additives across the agricultural practices of the entire Western world - and increasingly the developing world - has contributed to the introduction of known toxins into the environment at apocalyptic levels. They interact with and are absorbed by soils, bodies of water, vegetation, fish, and wildlife. They are absorbed and integrated into plant and animal tissues. As humans, we breathe in these compounds, eat them, drink them, and accumulate them in our bodies. We also excrete them, or their metabolized by-products, back into the environment, furthering the cycle of death and destruction brought on by these toxins. While further research is needed to expand our understanding of exactly how these toxins interact to produce disease and death, there is little debate about the importance of limiting environmental and dietary exposure to these toxins in the first place. Certified "ORGANIC" Foods and Heavy Metals Body Interaction with Heavy Metals Certified "ORGANIC" Foods and Heavy Metals Dietary exposure to toxic heavy metals through foods is a far greater problem than what most people realize. Even USDA-certified organic foods are not tested for heavy metals like cadmium, lead, arsenic, or mercury. Thus, there are no limits on heavy metal levels in these foods, including those sold in upscale healthy food retailers such as Whole Foods. The organic label simply describes the process through which the food was grown and that a farmer hasn’t used additional pesticides, herbicides, or other petrochemicals during that process. “Certified organic” in no way requires any heavy metals testing of soils, irrigation water, or even the final food product. The reality is that one farmer’s “organic” food can differ widely from another farmer’s food simply because the air, water, and soil in which the food is grown is overwhelmingly contaminated with heavy metals. Toxic heavy metals and other elemental poisons—whether they circulate around us or are absorbed into our bodies—definitively remain in the biosphere in one form or another in perpetuity. They are part of a vicious and deadly cycle that modern life has exponentially accelerated through the industrial mining, concentration, and dispersing of toxic elements that would have been far better left alone, buried in the Earth’s crust. Food Contaminates Aspartame, Monosodium Glutamate, Artificial Colors, Chemical Preservatives, Emulsifiers and Thickening Agents are now part of a widespread contamination of the food we eat. What’s worse, while everyone is focused on fat, calories, carbohydrates, and, in some cases, food preservatives, few are really paying attention to chemicals that may be unlabeled in their groceries or even in the packaging that their food comes in. Problem is that most of these complex lab creations aren’t recognized by the body so they cannot be properly processed. As a result, they often become hazardous to our health. The health risks behind each of the above "INGREDIENTS" are numerous but the bottomline is quite simple TRY TO AVOID PROCESSED FOODS! As an EXAMPLE: Mike Adams in his book FOOD FORENSICS (page 69) describes his attempt to persuade Whole Foods to pull the lead-contaminated protein powders from their store shelves, "the retailer did nothing to halt their sales of such products. Whole Foods continues to sell vegan, organic protein powders in its stores that show alarming concentrations of lead contamination because the raw materials are sourced from China." Transgenerational Toxicity Transfer Body Interaction with Heavy Metals There is ample evidence of heavy metals disrupting chemical reactions throughout the body and blocking important nutrient absorption. Toxic metals often compete with nutritional elements in metabolic processes; poisonous metals can imitate essential, or “good,” trace metals, rendering elements the body needs unavailable as chemical catalysts. Even when heavy metals don’t interfere with key metabolic functions, they still cling to cell walls, interfering with other cellular functions such as waste excretion, immune defense, healing, and adaptation. Emerging science reveals that toxic elements, including heavy metals, have a greater propensity than previously thought for damaging DNA and disrupting cellular processes. Not only are these metals shown to cause cancer, but there is increasing evidence now confirming their potential roles as co-carcinogens that increase mutations and disruptions when combined in the body with other types of toxins. Transgenerational Toxicity Transfer This recent (Published on Feb. 2022) study concludes: "Epigenetic transgenerational inheritance of increased susceptibility to disease is an example of generational toxicity, in which toxicants affect non-exposed future generations. Governmental policies regulating toxicant exposure currently do not take generational effects into account". Epigenetic inheritance of toxic side effects from dietary exposure to heavy metals means that toxicity is trans-generational. This means that the toxic environment in which we live today will negatively impact future generations for an unknown number of generations even if we eliminate all toxin exposure starting tomorrow. This way, studies have shown an inverse relationship between a mother’s cumulative cord blood lead levels and the epigenome of her developing fetus, strongly suggesting that toxins interfere with “long-term epigenetic programming and disease susceptibility.” Arsenic exposure was likewise found to affect DNA methylation in fetal development, damaging DNA and disrupting gene regulation.

Heart health and the contribution of the microbiome and diet to its maintanence. Info on heart health with respect to collesterol and statins. Heart and Heart Health Page Content: What is a heart attack Unorthodox Perceptions of Heart Failure Life style and the heart Heart Aging and the Role of SIRT2 Protein A healthy diet Cholesterol and heart condition Some facts about cho lesterol Cholesterol level and our diet What is the "right" cholesterol level Insulin Resistance Statins May Make Heart Health Worse Statins, Cholesterol Reduction and Myelin Additional indicators to heart risk Inflammation and Heart Disease Thyroid Health and Heart Disease What is a heart attack? What Is a Heart Attack? Your heart is an extraordinary organ that can function even when detached from your body as long as it is supplied with an adequate amount of oxygen. It works relentlessly to pump blood throughout your body and beats nearly 100,000 times every day, So it is crucial the muscle receives enough oxygenated blood and nutrients or it can die. Other than routine check-ups and test results, Heart Attacks are mostly originate with a chest pain . Common causes of heart-related chest pain include heart attack, angina, myocarditis and pericarditis. Plaque buildup in your arteries or narrowing of arteries, blocking the blood flow to the heart are a common reason to detrimental loss of blood supply to the heart. Although sometimes used interchangeably, a heart attack and cardiac arrest are two different occurrences. Sudden, unexpected cardiac arrest is the third leading cause of death in the U.S. but it is different from a heart attack. The most immediate and recognizable difference is that a heart attack victim will remain conscious with their heart beating, while someone who suffers a sudden cardiac arrest will be unconscious with no discernible heartbeat. While a heart attack affects the oxygen supply to the heart muscle, cardiac arrest affects the electrical impulses. During a heart attack, part of the heart may have a reduction in oxygen supply if the blood is restricted, but the remaining areas of the muscle will continue to beat Still, a heart attack can easily trigger a cardiac arrest! A loss of oxygen supply to the heart muscle from a heart attack affects the electrical impulses and may trigger a cardiac arrest. During a cardiac arrest, the electrical system is impacted by physical conditions, such as cardiomyopathy, heart failure or arrhythmias. This is perhaps the most common reason for a sudden cardiac arrest. Unorthodox Perceptions of Heart failure The above heart failure narrative is called - "the clogged pipeline theory". The strength of the pipeline theory is that it is simple, logical, clear and very visual. The cardiologist's role then, many times, is simply to open the blockages with drugs, stents or bypass surgery. Still, scientific research simply shows, time and again, that, it is not "the clogging" that triggers the heart problem. In most cases it does not help at all (pay attention to the references cited from the three leading journals in medicine - [1] ,[2] ,[3] ) Could it be that the "clogged pipe theory" is incorrect or at best only partial? Quite a few other scientific theories, try to give an explanation and even challenge the bread and butter of cardiology - the cholesterol-lowering drugs, catheters and bypass surgery. Here are two of these theories: Dr Matthias Rath, a doctor and researcher of German origin asks three interesting questions: Why are there no other body organ failures as a result of clogging, but only heart attacks? Why do only the arteries "get" atherosclerosis? Why is there no atherosclerosis of the veins? Why do only humans have heart attacks and animals don't? The vast majority of mammals know how to produce vitamin C themselves. We humans lost this ability in the distant evolutionary past, and we rely on vitamin C only from our diet. Vitamin C is necessary to create collagen. The collagen protein repairs defects that form in the inner cell layer of the arteries. The collagen does many other good things. When there is a partial deficiency of vitamin C, especially in the arteries of the heart, the repair ability of the blood vessels is impaired. To compensate for this, the body activates another repair mechanism that relies on a sticky particle called lipoprotein (LPa). This particle sinks into the walls of the blood vessels, in places of weakness, to repair and strengthen them. Over the years, this mechanism works excessively and slowly forms a layer of calcified connective tissue known as Atherosclerosis. LPa is a particle that has been studied for many years. A high level of it in the blood is linked to a variety of heart diseases and especially to ischemic heart disease[4 ],[5 ]. It can even be easily checked with routine blood tests. Why didn't your doctor ever prescribe you to do the test? Good question. Probably because the cardiologists don't check for it either. Why? I don't really know. Dr. Rath offers a fairly simple treatment based on vitamins (mainly vitamin C), minerals and amino acids [6 ]. By this treatment, the body improves collagen production and does not need to use LPa. Dr. Tom Cowan in his book Human Heart, Cosmic Heart offers another explanation which based on the following observations: All pathological studies conducted on people who died of a heart attack - looking under a microscope at the deceased's heart arteries, revealed that in most of them, there was no blockage of the coronary artery supplying the infarcted area (see pages 56-59). The body knows, almost without exception, to produce a collateral vascular system of new blood vessels that bypass any blockage, no matter how big. The pathological studies showed that the more time that passes from the heart attack to the death of the inflicted person, the more likely it is that there will be a blockage of a heart vessel. That is, the blood vessel blockage, if it happens at all, is the result of the heart attack and not the cause of it. The overall tone of the heart is controlled by the sympathetic system and its well-known hormone, adrenaline. When we sleep/relax/eat, the general tone of the heart is regulated by the parasympathetic system and its main nerve - the vagus. Increased sympathetic tone over time, accompanied by weakened parasympathetic tone, makes the heart vulnerable to acute events, which at once increase sympathetic tone. Emotional stress (on Mondays upon returning to work, there are more heart attacks in the US than the rest of the week) or intense physical activity, or a sudden hormonal change, such as what happens when we get up in the morning [8 ], cause the heart muscle to overexert itself and go into a metabolic state where it produces too much lactic acid . Any other overworked muscle in the body announces its fatigue by a burning sensation and pain caused by the lactic acid (without any problem with the blood flow). In the case of voluntary muscles, we simply stop the activity, take a rest, and allow the body to clear the lactic acid and recover. The heart cannot rest. It must continue to contract. When the heart cells become acidic, a chain of reactions begins that leads, eventually, to an accelerated decrease in cell function and, in the extreme case of a heart attack, to their death. A section of heart cells that are suffering and undergo edematous, will cause the blood vessels that supply oxygen to that area of the heart cells to be under pressure and inflammatory condition that could lead to a sudden blood clot. In other words, this blood clot is the result of deleterious conditions and not the trigger for the damage. In such an acute and catastrophic case, it makes sense to try to open the blood vessel by dissolving the clot or performing catheterization to open the blocked blood vessel segment with a balloon and/or a stent. In any other situation (such as the very common scenario in which heart disease is detected by a stress test or when blockages are detected by elective catheterization), catheterization will not help, since the problem is not there, but in the imbalance of the autonomic system, which causes the heart muscle to tire and accumulate lactic acid. Watch this video dealing with Catheterization, that shows a complete blockage in a major blood vessel of the heart and still, the blood vessel after the blockage is completely full of blood. These are the natural bypasses that the heart produces en masse so that the blood flow to the heart continues at full strength regardless of the blockages that are created (with the exception of a number of critical blockages that are created due to their very poor location). In conclusion, the theme promoted by the medical establishment: "bad cholesterol clogs the arteries - clogged arteries cause a heart attack - a heart attack kills", is very easy to understand and embrace the "actors" recommendations. The actors in the dramatic play are excellent actors - professors, pharmaceutical companies, medical boards, but the connection between the play and reality itself, may be completely coincidental. Unorthodox Perceeptions of Heart Failure Life style and the heart Heart Aging and the Role of SIRT2 Protein Life style and the heart The biological aging of the heart is a major risk factor, and yes, relaxation, healthy diet that is rich with vitamin C and collagen, exercises, no smoking, detoxification and some more are well established components of healthy aging of the heart (and the body). In the following sections we review with some greater details some elements of heart health at the molecular level - what exactly is happening in our heart cells that impacts heart aging, followed with practical actions in terms of what can we do to improve: Heart Aging and the Role of SIRT2 Protein A research published in Nature , focuses on the role of a protein called SIRT2 (a member of the sirtuin protein family) in the aging of the heart. It turns out that as we age, the level of this protein in the heart decreases. The researchers (in the article) showed two things that show how the presence of SIRT2 is related to the aging of the heart: If you engineer heart cells so that the level of SIRT2 will be lower, you get young cells...with the function of old cells. In other words, lowering the level of this protein is enough to accelerate the aging of heart cells. If you increase the level of SIRT2 in older heart cells, you reduce the symptoms of aging, even though the cells are already older!!! Consider it as the molecular fountain of youth of the heart! Raising the level of SIRT2 in the heart . As it turns out, there are some everyday things that increase the activity of SIRT2: Fasting : Fasting and caloric restrictions are well-known triggers of several members of the sirtuin family, including SIRT2[1 ][2 ]. Turmeric (Curcumin) : It turns out that one of the things it does very well is activate the sirtuins. For example, Research on worms showed that turmeric extends their life (the bottom line in improving health), and that this beneficial effect depends on the production of SIRT2. In relation to turmeric, it is important to note that consuming it with black pepper, improves its absorption significantly , 20 times, so it is recommended to do it More about SIRT2: It is a protein that regulates the action of other proteins by their deacetylation , namely - "peeling off" of a small molecule called acetyl, a molecule that plays a central role in those protein's cellular metabolism (Read more below ), proteins that serve as a key intermediaries in numerous metabolic pathways[1 ][2 ]. Its primary functions include: Energy production: Acetyl-CoA enters the citric acid cycle (Krebs cycle) in mitochondria, where it is oxidized to generate ATP, NADH, and FADH2[1 ][5 ]. Lipid synthesis: In the cytoplasm, acetyl-CoA acts as a building block for fatty acid and cholesterol synthesis[2 ] [4 ]. Protein acetylation: Acetyl-CoA serves as a substrate for histone acetyltransferases (HATs), influencing gene expression through histone acetylation[2 ][3 ]. Ketone body production: In the liver, mitochondrial acetyl-CoA is used to synthesize ketone bodies during periods of carbohydrate scarcity[5 ]. Carbohydrate metabolism: Acetyl-CoA is produced from the breakdown of glucose through glycolysis and pyruvate dehydrogenase complex activity[1 ][6 ] . Amino acid metabolism: Acetyl-CoA participates in the metabolism of certain amino acids[4 ]. A healthy diet - protecting and improving the gut microbiota we already discussed at length the importance of our diet as a preventive measure. "Taking care" of our heart is no exception. These two scientific articles are just another corroboration of this element: The Role of Gut Microbiota on Insulin Resistance Role and Effective Therapeutic Target of Gut Microbiota in Heart Failure, Additional parameters: Normal body mass index (BMI) Getting at least 2.5 hours of exercise each week and watching television seven or fewer hours per week Avoiding smoking Limiting alcohol to one drink or less per day. A Healthy Diet Cholesterol and heart condition Cholesterol and heart conditions: Cholesterol has been a highly publicized "scapegoat" for causing heart disease for decades. As a result, many have diligently cut all cholesterol-rich foods (which are often also nutrient-rich foods) from their diets. As precautionary measure, more than 1 in 4 Americans over 45 take cholesterol-lowering statin drugs at the behest of their physicians, despite their lengthy list of side effects and dubious effectiveness. and the underlying question that is: do we really need to be worried about cholesterol? The problem is not cholesterol levels but rather the development of insulin resistance (IR)! Insulin resistance is strongly associated with cardiovascular diseases (CVD). Insulin resistance, characterized by the body's decreased response to insulin, leads to several metabolic alterations that contribute to the development of CVD. IR is a condition encompassing hyperglycemia and compensatory hyperinsulinemia. It occurs when insulin is not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver and adipose tissue. This alteration of insulin signaling pathways results in the development of cardiometabolic disorders, including obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction and hypertension, all of which are predisposing factors for atherosclerosis and CVD. Some facts about cholesterol: Cholesterol is important to our body! our liver makes about three-quarters or more of your body's cholesterol—that's how important it is. Many of the healthiest foods happen to be rich in cholesterol (and saturated fats ), yet cholesterol has been demonized since the early 1950s following the popularization of Ancel Keys' flawed research . Is high total cholesterol and/or elevated low-density lipoprotein (LDL) cholesterol indicative of elevated heart disease risk ? With regard to total cholesterol, as far back as 1977, with the publication of the Framingham Study , no correlation between heart disease and total cholesterol could be found. Further research showed that the problem is not cholesterol but oxidized LDL. “Is the oxidized LDL a bad player?” Ali asks , “[or] is it there to protect us from oxidative injury? Rather than letting the important cells get oxidized, is the LDL sacrificing itself in protecting the body? Then, your whole paradigm changes ... LDL is not a bad player — it’s trying to protect us. What I need to figure out is how do I prevent this oxidative injury in the first place, and an argument that should surface is that, maybe I should have more LDL around so that oxidative injury can be ... prevented, rather than having less LDL? These are the kinds of fundamental questions that science should be asking.” Note the link between polyunsaturated fats (PUFAs), lipoprotein(a) [Lp(a)], and oxidized low-density lipoprotein (LDL) - the higher PUFA level in the blood, the higher the levels of arachidonic acid in plasma, which is linked to elevated Lp(a) concentrations. "The primary way to prevent atherosclerosis, then, is to radically reduce your LA (Linoleic Acid) intake by eliminating seed oils from your cooking, and avoiding processed foods (which are loaded with seed oils) and restaurant foods (as most are cooked in seed oils)." Cholesterol has many health benefits. It plays a key role in regulating protein pathways involved in cell signaling and may also regulate other cellular processes, for instance. It's already known that cholesterol plays a critical role within your cell membranes, but research suggests cholesterol also interacts with proteins inside our cells. Cholesterol is one of the molecules that allow for these interactions to take place. For example, cholesterol is the precursor to bile acids, so without sufficient amounts of cholesterol, your digestive system can be adversely affected. It also plays an essential role in our brain, which contains about 25 percent of the cholesterol in our body. It is critical for synapse formation, i.e. the connections between your neurons, which allow us to think, learn new things, and form memories. Some facts about cholesterol Cholesterol and our diet Cholesterol blood Level and our diet Cholesterol level is not the result of what we eat! The regulation of HDL and LDL cholesterol levels involves several interconnected body mechanisms: The biggest factor in cholesterol is not diet but genetics or heredity. Our liver is designed to remove excess cholesterol from our body, but genetics play a large part in our liver's ability to regulate cholesterol to a healthy level. Take, for instance, people with genetic familial hypercholesterolemia. This is a condition characterized by abnormally high cholesterol, which tends to be resistant to lowering with lifestyle strategies like diet and exercise. Further, eating nutritious cholesterol-rich foods is not something we should feel guilty about; they're good for us and will not drive up our cholesterol levels as we may have been told. To date, extensiv e research did not show evidence to support a role of dietary cholesterol in the development of CVD. It is worth noting that most foods that are rich in cholesterol are also high in saturated fatty acids and thus may increase the risk of CVD due to the saturated fatty acid content. What is the "Right" Cholesterol Level: In recent years, there is a growing number of studies that show that higher cholesterol levels of both HDL and LDL types are associated with prolonged life expectancy [REF1 ], [REF2 ]. Not only that cholesterol levels of 252 mg/dl were found to be associated with prolonged life expectancy, but there are many articles [REF3 ], [REF4 ], [REF5 ] that presents the rational for these findings. Bottom line, cholesterol level is a body "built in" response to various nutritional and other health conditions (like chronic inflammation, insulin resistance and more) and therefore it makes no sense to take medications to lower the cholesterol level (which impedes the body's positive reactions), rather than dealing with the issues that triggered this reaction. Insulin Resistance "Multiple studies have demonstrated that insulin resistance is a strong predictor of atherosclerotic cardiovascular (CV) disease (ASCVD) and have been summarized in a recent meta-analysis by Gast et al" . Insulin resistance (IR) has profound implications for vascular health, contributing to both functional and structural damage in blood vessels. Below is an overview of its effects: Impaired endothelial function (the control of blood fluidity, platelet aggregation and vascular tone) : Insulin resistance is associated with endothelial dysfunction , which is characterized by reduced production of nitric oxide, increased inflammation, and oxidative stress in the endothelial cells lining blood vessels. Endothelial dysfunction limits the ability of the blood vessels to repair damage caused by blood vessels inflammation, as it interferes with the normal processes of the widening of blood vessels (vasodilation) and the recruitment of repair cells to damaged areas. Decreased nitric oxide production : Insulin resistance can lead to decreased production of nitric oxide , a molecule that plays a key role in maintaining the health and function of blood vessels. Nitric oxide helps to regulate vascular tone, inhibit platelet aggregation, and prevent leukocyte adhesion to the endothelium (a single layer of cells, called endothelial cells, which line all your blood vessels and lymphatic vessels). Reduced nitric oxide levels impair the ability of blood vessels to respond to injury and promote repair processes. Pro-inflammatory state : Insulin resistance is associated with a chronic low-grade inflammatory state characterized by elevated levels of inflammatory cytokines and chemokines. This systemic inflammation can further damage the endothelium and impair repair mechanisms in response to inflammation induced injury. Additionally, inflammation promotes the development and progression of atherosclerosis, further compromising vascular repair. Hyperglycemia-induced damage : Insulin resistance is often associated with hyperglycemia (high blood sugar levels), which can lead to the formation of advanced glycation end products (AGEs). AGEs contribute to endothelial dysfunction, oxidative stress, and inflammation, all of which impair the ability of the cardiovascular system to repair damage caused by inflammation. Overall, insulin resistance contributes to a pro-atherogenic environment characterized by endothelial dysfunction, inflammation, dyslipidemia, and hyperglycemia, which collectively limit the ability of the cardiovascular system to repair damage caused by blood vessels inflammation, and promote the progression of atherosclerosis and cardiovascular disease. "The molecular etiology (etiology = attribution of the cause or reason for something) of the insulin resistance directly contributes to the development of atherosclerotic cardiovascular disease by inhibiting nitric oxide production (endothelial dysfunction) and stimulating the MAPK pathway". In conclusion of the above section, lowering insulin resistance is the most important action to reduce CHD risk! Our recommended diet , that includes intermittent fasting and physical exercises is most likely to provide the desired results. STATINS "Of note despite the ability of statins to lower LDL-C, non-HDL-C, and apolipoprotein B levels, statins do not lower Lp(a) (Lipoprotein (a)) levels and may even increase levels (10 ,11 ). Finally, statins modestly increase HDL-C levels (8 ,12 ,13 ). In most studies HDL-C levels increase between 5-10% with statin therapy". Statins May Make Heart Health Worse There is evidence showing that statins may worsen heart health, and only appear effective due to statistical deception. One scientific study concludes : "Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms". Another study brings this conclusion : "How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease" This study shows that "Use of the statin medications routinely result in lower coenzyme Q10 (CoQ10) levels in the serum . Some studies have also shown reduction of coenzyme Q10 in muscle tissue. Such coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies." "Myopathies are a heterogeneous group of disorders primarily affecting the skeletal muscle structure, metabolism, or channel function. They usually present with muscle weakness interfering in daily life activities. Muscle pain is also a common finding and some myopathies are associated with rhabdomyolysis". CoQ10 is crucial for efficiently transferring electrons within the mitochondrial oxidative respiratory chain and producing adenosine triphosphate (ATP) . ATP is a coenzyme used as an energy carrier in every cell of our body. When we consider that our heart is the most energy-demanding organ in our body, we can surmise how potentially devastating it can be to deplete our body's main source of cellular energy. So while one of statins' claims to fame is warding off heart disease, scientific studies show that they actually increase our risk of depleting our body of CoQ10. The depletion of CoQ10 caused by the drug is why statins can increase our risk of acute heart failure. Statins, Cholesterol Reduction and Myelin Given the discussion in this section about the importance of cholesterol for the production of myelin, and the importance of myelin to cognitive functioning, it is not surprising that dementia and altzheimer disease rapidly increased with the expansion of statins usage as shown by these numbers from QuickStats: "Age-Adjusted Death Rates for Alzheimer Disease Among Adults Aged ≥65 Years, by Sex — National Vital Statistics System, United States, 1999–2019. The age-adjusted death rate for Alzheimer disease increased from 128.8 per 100,000 in 1999 to 233.8 in 2019.23 (Apr 2021) " Anyone who takes a statin drug, MUST take Coenzyme Q10 as a supplement. For those who are over 40, it is strongly recommend to take ubiquinol (CoQ10's reduced form) instead of CoQ10, as it's far more effectively absorbed by our body. What is the "right" Cholesterol Level Statins May Make Heart Health Worse Insulin Resistance Statins, Cholesterol Reduction and Myelin Inflammation and Heart Desease Thyroid Health and Heart Disease Additional indicators to assess heart disease risk : Fasting insulin level test : The normal fasting blood insulin level after a night of fasting varies, but generally falls within the range of 2-12 μU/mL (or μIU/mL) for the general population. Excess fat , particularly around our belly, is one of the major contributors to heart disease, Fasting blood sugar level test: This test measures your blood sugar after an overnight fast (not eating). The normal blood sugar level after a night of fasting (typically 8 hours or more) is between 70 to 99 mg/dL (3.9 to 5.5 mmol/L) " Coronary-heart-disease (CHD) mortality was approximately doubled for subjects with inpaired glucose tolerance (IGT), defined as a blood-sugar above the 95th centile (greater than or equal to 96 mg/dl)". Iron level: Iron can be a very potent oxidative stress, excess iron levels can damage blood vessels and increase the risk of heart disease. Ideally, ferritin levels should be monitored to make sure that they are not much above 80 ng/ml. The simplest way to lower elevated iron level, is to donate blood. If that is not possible, a therapeutic phlebotomy can effectively eliminate the excess iron from our body. Inflammation and Heart Disease I nflammation may promote the growth of plaques , loosen plaque in your arteries and trigger blood clots — the primary cause of heart attacks and strokes. When a blood clot blocks an artery to the heart, you have a heart attack. Thyroid Health and Heart Disease Thyroid hormone (TH) has a fundamental role in cardiovascular homeostasis in both physiological and pathological conditions, influencing cardiac contractility, heart rate, diastolic function and systemic vascular resistance through genomic and non-genomic mediated effects. In heart failure the main alteration of thyroid function is referred to as "low-triiodothyronine syndrome" characterized by decreased total serum (T3) and free T3 with normal levels of thyroxine and thyrotropin. Patients with baseline or new-onset abnormal thyroid function had a higher mortality than those with normal thyroid function, even after controlling for other known mortality predictors. Vascular oxidative stress and inflammation are major determinants of endothelial function. "Endothelial dysfunction is an early predictor of atherosclerosis and future cardiovascular events"! Endothelial dysfunction is a type of non-obstructive coronary artery disease in which there are no heart artery blockages, but the large blood vessels on the heart's surface constrict (narrow) instead of dilating (opening). This condition tends to affect more women than men and causes chronic chest pain. Thyroid hormone (TH) has a fundamental role in cardiovascular homeostasis in both physiological and pathological conditions, influencing cardiac contractility, heart rate, diastolic function and systemic vascular resistance through genomic and non-genomic mediated effects. In heart failure the main alteration of thyroid function is referred to as "low-triiodothyronine syndrome" characterized by decreased total serum (T3) and free T3 with normal levels of thyroxine and thyrotropin. Patients with baseline or new-onset abnormal thyroid function had a higher mortality than those with normal thyroid function, even after controlling for other known mortality predictors. Vascular oxidative stress and inflammation are major determinants of endothelial function. "Endothelial dysfunction is an early predictor of atherosclerosis and future cardiovascular events"! Endothelial dysfunction is a type of non-obstructive coronary artery disease in which there are no heart artery blockages, but the large blood vessels on the heart's surface constrict (narrow) instead of dilating (opening). This condition tends to affect more women than men and causes chronic chest pain. Additional indicators to assess heart disease risk

halyvera, the gate for self healing practices collected and corroborated from scientific studies and reviewed by site members. No ads or promos. ABOUT US AND THIS WEBSITE BE IN TOUCH Page Content: Our Mission Who We are Unbiased Information And Practices Scientifically Backed Facts Why Self-Healing Why We Do It Knowledge Sharing What's Special About The Halyvera Website the high tech vets that became herbal and commit to share their self-healing practices with others Our Mission Who We Are UNBIASED INFORMATION AND PRACTICES Scientifically Backed Facts Why Self-Healing Our Mission To provide community members with scientifically backed herbal self healing health related practices, products and related information along with members’ testimonials. Offered products will be only of top quality at substantially lower prices than any other similar product on the market. Who We Are We are a group of Israeli entrepreneurs, vets of the high-tech sector who discovered the benefits of self-healing herbal based practices, practices that helped us restore our confidence in our ability to control our well-being. Unbiased Information And Practices Unbiased and trustworthy information is at the foundation of this website. No advertisements, member reviews will be meticulously scrutinised to prevent product promotions of any sort! Most important is the fact that we are not promoting any product to avoid any incentive for biassed information. Our product offerings are very limited and we offer them because we found supply chains that make them top quality at unmatched prices! No product will be offered on this website unless it is organic (if grown or harvested), with substantiated heritage of results, and certificates of product integrity (in special cases - presence of heavy metals tests). Nor will we share community subscribers' emails or any other contact information with any third party. If and when we will offer a product, it will be to create an offering of quality and price as a challenge for other vendors to meet and surpass. Scientifically Backed Facts We commit to avoid recommending recipes, practices, and applications that are not backed by scientific studies. Some of the recipes, in particular hair growth recipes, are presented after we validated that they are popular and represent a heritage of centuries-old tradition because we attribute high credibility to health practices that were evolved through centuries of practice and come from reliable sources, like the Father Romano Zago recommended practices. Why We Do It Knowledge Sharing Why Self-Healing? Self-healing is first and foremost - taking responsibility to your health , translated to preventive practices like your daily diet and physical exercises, two basic elements that without them, all other practices will be less effective, and their impact would not last for long! Most of today's prescriptions and medical practices are effective and provide remedies for the problem that they are prescribed to resolve. The problem - PRESCRIPTIONS DO NOT COPE WITH THE PROBLEM CAUSES and their side effects could some times lead to other complexities. Just as an example, Type 2 diabetes medications and insulin therapy - Metformine (Glucophage, Glumetza, others) are "doing the job" but the pancreas insulin secretion will most likely become dysfunctional. Same with the thyroid triiodothyronine (T3) and thyroxine (T4) hormone secretion that becomes essentially ineffectual over time of taking the replacing medications. Eyeglasses are another good example, as corrective eyesight practices such as glasses, contact lenses, LASIK or other laser interventions further weaken eyesight over a prolonged period of time. Self-healing practices can help alleviate problems, without long term detrimental side effects! As high-tech vets, we continuously and relentlessly search "out of the box solutions" to discover what others have been developing below our own "radar". WHY WE DO IT? There was a point in time that we asked ourselves - What has been our contribution to the community. Follow-up questions were: What community? What is a contribution to the community? Without diving deep into a philosophical discussion, this website is the answer we found for these two questions. We strongly believe that it is up to us to prove to the community members, that what we promise, is what we deliver. We strongly believe in prevention practices, rather than fixing various health conditions. WHAT MAKES THE HALYVERA WEBSITE SPECIAL KNOWLEDGE SHARING Knowledge sharing is key to this process of taking responsibility for our health and applying the preventive or healing practices that are the basis of what self-healing and herbal health have to offer. We take responsibility - We will do our best, that this website will be an unbiased stage for users to share their experience, with what worked and what did not work for them, using the REVIEWS inserts that are attached to the prescribed practices. THIS IS WHAT WE CALL CROWD WISDOM. “What works for me”! is a corner stone of this site. Dealing with a health problem, finding “a solution that works for you” is a "never ending" challenge, because what works (or does not work) for one, may not work for another. Crowd wisdom is so important because it gives you access to the experience of others. We will do our utmost to provide detailed "PRACTICES"! But we need your help! help us and point to deficiencies, and we will get back to you with the missing elements and our thanks for your cooperation. WHAT MAKES THE HALYVERA WEBSITE SPECIAL This website is for those who decided to take control of their health and wellbeing. For decades, populations of “modern/western societies'' were educated/led to accept/adopt practices/treatment protocols provided by the medical establishment! FOR A RAPIDLY GROWING GLOBAL COMMUNITY OF PEOPLE, THESE DAYS ARE OVER! People in many countries become aware, that the medical establishment in their country as in many other parts of the world, has been manipulated by some very powerful medical entities represented by the WHO (World Health Organization), to prescribe health protocols that serve the interests of the dominating pharmaceutical corporations, as well as other interests, and not the interest of the individuals that they were suppose to serve! Consequently, when one asks for a doctor’s advice, or seeks help in the hospital, the prescribed medicine/treatment would not be what’s best for him, but what’s best in terms of these dominating powerful entities. Those who become “AWARE” to this institutional misconduct, are now in search for UNBIASED, “PROVEN” protocols/practices that would be the best fit for the problems that they have to cope with. This is the community we are targeting with the HALYVERA website. The site’s main topics are “HEALTH ISSUE” and “PREVENTION”. HEALTH ISSUES contains suggested practices to deal with various most common health issues, PREVENTION contains practices to help avoidance of the various health issues. All the practices prescribed for both - ISSUES and PREVENTION are provided with detailed scientific backing to their validity, effectiveness and safety. To avoid any conflict of interests, the products that are offered on our website are there for one reason, to provide the best quality product for the prescribed practice at the lowest cost possible. Other vendors are encouraged to provide alternatives that will be posted as soon as they are validated for the quality and the price of their offerings. Off course, HALYVERA is not the first website that seeks to attract and serve this community, but it contains some features that are unique in terms of improved accessibility/navigation of site visitors who are in search for some specific information: PAGE CONTENT box with links to specific topics presented on each page, REVIEWS inserts for each of the suggested practices, providing site visitors with the feedback of those who have already tried that practice, RELATED PAGES links, to provide short-cuts to pages containing additional information related to the information posted in the page. WHY WE DO IT? Our biggest compensation would be if we succeed to accelerate the spreading of this “AWARENESS”. We ourselves became aware of our own misconception - the perception that the medical establishment seeks to help us and not serve its own interests, by people that decided to give up their careers and devote their skills and energies for this eye opening. If successful, this website would be our minor return to what these people have contributed to us!

BLOG What Aloin Is Good for? "Is aloin toxic" is discussed in detail in this section . Still, there is no doubt that aloin contains some very powerful anti-inflammatory and skin nutritional ingredients, and so far no toxicity has been reported when it is used topically! Yes, there are those who may be sensitive to it, but this sensitivity can be detected easily by following the instructions below [REF ] (or some more “relaxed” version of that procedure): Apply the product to a test spot twice daily for seven to 10 days. Choose a quarter-sized spot on your skin where the product won’t be rubbed or washed away, such as the underside of your arm or the bend of your elbow. Use the normal amount and thickness you would use as if you were applying the product regularly. Leave the product on your skin for as long as you would normally. If you’re testing something that you would usually wash off, like a cleanser, keep it on your skin for five minutes or as long as the instructions say. If after seven to 10 days you don’t have a skin reaction, such as red, itchy, or swollen skin, go ahead and use the product. Assuming that no sensitivity is observed, the aloin scraped with the gel from the inner side of a fresh aloe leaf’s skin could be applied to recover (and improve) hair growth (video min 4:22), face masks (Video min 3:12, Video min 7:34) and many other applications. So why throw away the leaf’s peeled skin after extracting the gel for your daily smoothie as so many “experts” demonstrate (video min 5:41) in their videos? What is the Best Aloe Vera Drink? There are many Aloe Vera Beverages to choose from. Here we discuss some of the differences starting with the aloe “product” used and continue with the additives that may be used, to help you make the choice of what’s best for you! The prime/best aloe product to to construct your drink with is the inner leaf gel which is made right from the plant. It is not filtered, pasteurized, nor preserved. It does not have anything added. It does not contain thickeners or ingredients to change the texture, taste, color, or smell. Beware of drinks that contain thickeners such as carrageenan in them. Thickeners are added to make the drink appears more like true aloe vera gel. Real aloe vera gel does not need thickeners. If you have an aloe vera plant you can make your own aloe vera gel to drink. It is easy to make as we demonstrate in the next blog below. There are two additional categories of aloe products sold through various marketing channels: “Whole leaf aloe vera” gel/drink, for its laxative effect. Using this product does not allow the ingestion volume that you may desire if you were trying to heal inflammatory bowel or strengthen your immune system against significant illness. “Inner leaf aloe vera” products that were either processed in a way to minimise contamination from the outer leaf or they had the outer leaf “aloin” filtered out using processing agents such as activated carbon and diatomaceous earth. Of course, this processing significantly removes inner leaf nutrients as we present in this section . Some brands make both inner leaf gel AND whole leaf. Read the label to avoid getting the whole leaf by mistake when you only intended to get inner leaf gel. Consuming too much whole leaf aloe vera will send you to the facilities. Some aloe vera drinks have the aloe ingredient added as powder and listed in milligrams such as “300 mg. aloe vera”. These aren’t actually aloe vera drinks but instead juices that have a measured amount of aloe vera powder in them. It does not require a scientific study to learn not to expect a significant health benefit as you might with real aloe vera drinks. Back to the question of “Best Aloe Drink”, to gain the most out of its beneficial ingredients, it has to start with a freshly extracted gel. Real aloe vera inner leaf gel has only a mild bitterness and some claim that they detect a slight garlic and onion taste. All that you have to do to make it enjoyable, is to add coconut milk (marginal carbohydrates), some lemon juice and monk powder as a sweetener. Try this recipe (also good for Keto diet), and you will never look back (all ingredients should be organic) Put in your blender (most recommended to use only organic ingredients): 14 oz (400 grams) fillet pieces from the gel rich frozen aloe vera leaves (after skin peeling), , 14 oz (400 grams) coconut milk The pulp from half a lemon (scraped with a grapefruit spoon), 1-2 tablespoons of raw honey, 6 teaspoons of Monk Powder (use water to dissolved the powder at a ratio of 1 monk :2 water - boil the water and stir, let it simmer for about 15 min). Turn the blender on for a short blending action (preferably slow blending to avoid oxidation), t aste the blend, if you still feel some bitterness, add some raw honey to neutralize it. Enjoy the drink and refrigerate whatever that is left. Revolutionary Quick and Efficient Gel Extraction From The Aloe Leaf Many consider the aloe gel extraction, a messy and tedious undertaking. In this section (video min 5:43 - 5:50) we demonstrate how this extraction method makes the job quick, and with very little waste.

Vaccination Page Content: Background Vaccination Guidelines Vaccine Placebo Testing Child Illness Management Risking Others by not Vaccinating Not Vaccinated Spread Diseases Are Vaccines Truly Attenuated? Are Vaccines Behind Disease Control? Background Vaccination Guidelines Background Doctors want to do what is right, but who creates their curriculum or continuing education modules? The medical curriculum is devoid of important information on vaccines. What is the real truth? What is not told to doctors and the public? There is a continuous attempt to silence debate and discussion about the evidence and science in the medical literature, which speaks against the mainstream mantras. Hopefully, the medical articles, and links that follow below will provide you with access to information that is not taught in medical schools nor allowed in mainstream media. Vaccination Guidelines As an Example: In this American 1984 DHHS federal register, provides the final guidelines pertaining to the polio vaccination campaigns in the USA after three decades of controversy. These guidelines place many lives in jeopardy as major problems with vaccination were and are overlooked by vaccine policy makers. One such example: human milk contains a molecule called H.A.M.L.E.T. and many other immune components that assist the baby’s immunity during its anti-inflammatory phase, while successfully protecting from capsular bacterial infections. Optimal sequential induction of immune tolerance requires the normal, natural body programming. Vaccines are in complete opposition to this programming. There are aspects of immunity that vaccines could never help with. For some infants, the interruption of the normal immune clamped process with aluminum and vaccines, has the potential to cause life-long serious consequences. Watch this infant immunity series video and the information provided by Dr. Paul Thomas to learn more on children's susceptibility to vaccinations. There is a paucity of studies comparing never vaccinated children, with partially or fully vaccinated children. In 2017 two important articles were released regarding vaccinated and unvaccinated homeschooled children. The results should make any thoughtful scientist step back and ask what exactly vaccines are achieving. Please read both articles in full, Mawson 2017 pilot study , and Mawson 2017 preterm birth, vax, neuro disorders . In terms of safety studies, a major issue is that most vaccine studies use another vaccine or the background substance of the vaccine, as the control and call it placebo. There is one study (Cowling 2012 ) where a true saline placebo was used, rather than another vaccine or the carrier fluid containing everything except the main antigen. That study showed no difference in seasonal influenza viral infection between groups but astonishingly it revealed a higher pandemic strain infection rate and a 5-6 times higher rate of non-influenza viral infections in the vaccinated. It is no small wonder that more true placebos are not used in vaccine research. Vaccine Placebo Testing In this article, we see a clear example of how false placebos are regularly used. Furthermore, most vaccines have never undergone carcinogenicity testing, and rarely studied their effect in pregnant women, which results in people taking vaccines, either by a proclaimed “emergency”; by a “public health” order from the WHO; or by threats of loss of rights over one’s children or of imprisonment; or by threat of being abandoned by the medical professionals supposedly providing care. This has also been extended to medical staff who lose their jobs if they refuse to take any mandated vaccine. “Informed consent” is devoid of all meaning when people are tricked into taking vaccines by the use of misleading or frightening “information.” Vaccines Censoring Protection Repeatedly over the decades, published medical articles, which threaten the vaccine industry are often attacked, and where possible discredited, or journals are forced to retract the articles. Therefore doctors never get to use them as part of informed consent. Drs Gatti and Montenari wrote an article on their research findings in 2017. The ARTICLE was systematically attacked from the time it was printed. In February of 2018, Italians lost their rights to choose not to vaccinate their school age children. Shortly thereafter, Gatti and Montenari’s laboratory in Italy was raided, and all data and computers and personal devices in their homes were confiscated. HERE is a short article in English detailing what occurred. How can informed consent happen in this sort of environment? This isn’t the first time this has happened, Dr. Suzanne Humphries, “Honesty vs Policy ” that describes historical examples, has also been deleted from many channels, as publications by Dr Anthony Morris and many others. Vaccine Placebo Testing Vaccines Censoring Protection Child Illness Management If vaccinated or not, parents must learn the ways to take care of their children when they get the common childhood illnesses, since children can still get the diseases they were vaccinated against. In the case of unvaccinated children who experience childhood maladies, effective home-nursing allows children to recover naturally, and in most cases, the child will have long-term immunity. Infectious fevers must not be lowered as this does not help the child. In a short article Tapping the immune system’s secret the limitations of immunology are plainly spelled out. The public is repeatedly misinformed, underinformed, or frightened in order to maintain their participation in vaccination. All sorts of tactics are used. One of the most popular is to say that everyone should get vaccinated in order to protect the unvaccinated. This discussion is repeated in different forms as demonstrated in this article . An ARTICLE by Elahi in 2013, showed that infant immune cells have full functional capacity, but are clamped down to allow the infant to learn what is self, what is a healthy commensal micro-organism, and what should later be attacked. If you would like to learn more about neonatal immunity, read this 3-part blog series , and take note of the medical articles used. Child Illness Management Risking Others by not Vaccinating: What is the risk? Chicken pox? Ask your grandmother if she knew anyone who died from chicken pox or measles. Different diseases have different degrees of severity in different age groups. The misconception that “if you don’t vaccinate, you place others at risk” is based on an assumption that vaccinated people do not get the disease they were vaccinated for. Did you know that a controlled study published in BMJ in school age children showed that of all the whooping cough that was diagnosed, over 86% of the children were fully vaccinated and up to date for the whooping cough vaccine? There are similar studies showing that mumps and measles breakouts often affect the vaccinated. People who are vaccinated can have their immune systems altered in a manner that leads to susceptibility to other infectious diseases, and can also leave them vulnerable to the disease they were vaccinated for due to a phenomenon called “original antigenic sin”. What is “original antigenic sin”? This is where an injected vaccine antigen programs the body to react in a manner that is incomplete, and different to the natural response to infection . When the vaccinated contact that disease again, they are unable to mount an effective response to the pathogen because vital first steps are missing. The whooping cough vaccine is an example of this. A very noteworthy study was published in 2013, looking at baboons, which are susceptible and manifest whooping cough like humans do. In the study by Warfel, baboons that were either vaccinated or not vaccinated were later exposed to pertussis bacteria, something that cannot be done experimentally in humans (due to ethical considerations), but which yields very important data. As expected, the baboons that had never been infected got the cough and remained colonized with bacteria for a maximum of 38 days. But unexpectedly, baboons that were previously vaccinated and immunized vaccine-style, became colonized upon later exposure for a longer time than the naïve baboons; 42 days. However unvaccinated baboons that recovered naturally and were later exposed to the bacteria did not become colonized at all – zero days. Recuperated and vaccinated baboons were also exposed to pertussis bacteria and then placed in cages with naive baboons. Only the vaccinated baboons infected them . The naturally recovered baboons did not infect their naive cage mates. This video contains relevant information that every parent should know. So, who is providing better herd immunity in the face of whooping cough bacterial exposure? Vaccinated individuals who presume they are immune, yet remain asymptomatically colonized for 42 days spreading bacteria? Unvaccinated kids who get infected and remain colonized for 38 days? Or the naturally convalesced who are not able to be colonized and therefore do not spread bacteria at all upon re-exposure? Better still: natural convalescence makes for solid immunity which lasts decades longer than vaccination. Many vaccine enthusiasts like to invoke the term “herd immunity” to make the argument that the non-vaccinated pose a risk to the vaccinated. But the concept of herd immunity has no relevance to the vaccinated as it was coined in reference to natural immunity in populations and at what level the least epidemics occurred. There is no evidence whatsoever that having an 85% or 95% childhood vaccination rate necessarily protects from outbreaks. Risking Others by not Vaccinating Not Vaccinated Spread Disease Live vaccines are known to spread from one person to another on close contact. Here is one example . There has been a plethora of mumps outbreaks in mostly vaccinated populations. We also know that in pertussis (whooping cough), those who are vaccinated are more likely, due to original antigenic sin, to be carriers of the bacteria longer than the non-vaccinated, even when asymptomatic. In his ARTICLE published in Clinical Infectious Disease in 2004, Dr. James Cherry pointed out that adults, re-vaccinated against pertussis, don’t develop any antibacterial activity whatsoever. He went on to explain why. The current vaccines contain a few antigens, which create “original antigenic sin”, whereby the immune response to the vaccine is abnormal. That first-learned response then becomes the default position the immune system takes, on future booster shots. So in the case of the whooping cough vaccines there are key protein virulence factors which have not been included in the vaccines including ACT, TCF, TCT, as well as BrkA and DNT. Because the first three are not included, the default immune response does not prevent colonization. Furthermore, Cherry stated that the “original antigenic sin” results in the vaccinated being unable to clear the bacteria from their lungs. The non-vaccinated have immunity to all the front line virulence factors and very quickly clear the bacteria on re-exposure. Mothers who have been vaccinated, may develop surrogate markers which can be measured in a laboratory, but these do not guarantee efficient immune responses after exposure to the natural disease, because their first “learned response” was incorrect. Furthermore, they are still not sure “what” the surrogate marker actually is for pertussis. There is similar information on measles, the other disease that has been portrayed by the media as a danger to the population due to non-vaccinated children. But this information is not accurate, nor is measles a dangerous disease in healthy people who have sufficient vitamin A. Damien et. al pointed out in this ARTICLE that the vaccinated are 5-8 times more susceptible to asymptomatic infection than the immune non-vaccinated. How then, are the non-vaccinated solely responsible for the recent outbreaks in measles? Are Vaccines Truly Attenuated? Many vaccines are said to be “attenuated” or modified-live and supposedly do not infect, but over the decades we have seen how those attenuated viruses mutate once they are in a human and can spread more virulent disease than what is being vaccinated for. The oral polio vaccines in Nigeria today is a case in point. But this can happen with any attenuated viral vaccine. The original Salk polio vaccines were supposed to be killed vaccines and yet they infected thousands of people, the household contacts and the community, killing and paralyzing over 200 people. The published figure is thought to be a gross underestimate of the true number of people affected. Here are things to consider when you hear of an outbreak of an infectious disease: “How many of the affected were fully vaccinated and how many people died or were hospitalized? Were the cases verified with laboratory tests or are the reports based on community doctor reports? What drugs were given prior to death?” Not Vaccinated Spread Disease Are Vaccines Truly Attenuated? Are Vaccines Behind Disease Control? As we can see in Figure 1 below, the mortality from these diseases was drastically declining prior to vaccination. But in addition, you might want to know the more rational explanation for deadly disease decline in modern times. It’s not vaccination. It has been shown to be hygiene. In this article , “What is the causal link between hygiene and infections?” The authors offer epidemiological evidence that vaccines played a minor role. Here is something else you may not have been informed of: All the reduction, even for TB in the USA, was achieved BEFORE any vaccines of any sort were offered, and most of the reductions for all diseases were achieved before antibiotics became commercially available some time around 1950. So what did this reduction? It wasn’t vaccines. Yet all the countries which used the BCG (Bacillus Calmette–Guérin) vaccine as front line “protection”, saw an identical decline to the one which we saw in the USA using no TB vaccine. Mortality for several common illnesses had already declined significantly long before the vaccines were created. The downward trend of the curves is completely unaffected by vaccine introduction. If you compare the graphs for death decline in diphtheria and scarlet fever, they are almost identical. Yet there never was a widely used vaccine for scarlet fever. Scarlet fever and its resulting complication, rheumatic fever — has clearly been shown in the medical literature, to be nutritionally driven. This is why if you do find someone who says they had scarlet fever, it is primarily in more impoverished, war-torn, hungry and poverty stricken countries. In developed countries where rheumatic fever is an issue, it’s primarily seen in the less educated groups, whose nutritional understanding is lacking, or their access to good food is limited. Yet under-educated people in stable social environments, without much money, who understand and follow effective nutritional pathways, will be on the scale of low susceptibility because nutrition and well being, is what really counts. Are Vaccines Behind Disease Control? Figure 1 Poor nutrition is historically correlated with higher rheumatic fever and death. All of us carry Strep A regularly, but the well-fed amongst us don’t get scarlet fever, let alone its complication, rheumatic fever. This point is well studied enough to lay aside any concern over whether or not correlation implies causation. Historically, in the case of all infectious diseases, good quality nutrition has been and still is, a major preventive factor that has led to enormous declines of morbidity and mortality from most infectious diseases. It is no coincidence that in the UK, scurvy and measles mortality were closely correlated, as seen in the graph below, copied from Suzanne Humphries “Dissolving Illusions” .

Oregano oil and its carvacrol theraputic power as the most effective infection and inflamation depresent. How the right diet, reinforced with vitamins D and C (not ascorbic acid!) can subdue infection and inflamation. ENDOCRINE SYSTEM AND MICROBIOTA Page Content The Endocrine System The Hypothalamic–Pituitary–Thyroid axis The Hypothalamic–Pituitary–Adrenal axis Thyroid Disorders Hypothyroidism In Infants Thyroid's Health Melatonin and the Pineal Gland The endocrine system synthesizes and secrete hormones to regulate physiological processes. Interestingly the gut microbiome is an endocrine organ itself; metabolomic and metagenomic studies have revealed bacterial metabolites and components that affect organ function and subsequently, physiological outcomes. Endocrine System ENDOCRINE SYSTEM, GUT MICROBIOME AND OTHER DISRUPTORS Gut microbiome and the Endocrine (Glands Hormones) System A healthy gut microbiota not only has beneficial effects on the activity of the immune system, but also on the functioning of the endocrine system.This study concludes "Likewise, a role for the microbiota in the regulation of the HPA axis has been established as well as the serotonergic system via modulation of tryptophan availability. Unlike other endocrine organs, the microbiota has intense plasticity and can alter dramatically and rapidly in response to diet." Note ! "hypothalamic-pituitary-adrenal (HPA) axis, an intricate, yet robust, neuroendocrine mechanism that mediates the effects of stressors by regulating numerous physiological processes, such as metabolism, immune responses, and the autonomic nervous system (ANS)"More spicifically, "The composition of the gut microbiota has an influence on the availability of essential micronutrients for the thyroid gland.Iodine, iron, and copper are crucial for thyroid hormone synthesis, selenium and zinc are needed for converting T4 to T3, and vitamin D assists in regulating the immune response". The damage incurred to gut microbiota by drugs in general and antibiotic drugs in particular! The human gut microbiota has now been proved to be closely associated with drug responses and efficacy, while chemical compounds present in these drugs can also impact the gut bacteria. Some drugs with microbial features, proton-pump inhibitors, metformin, antibiotics and laxatives show the strongest impact and associations with the microbiome. Read more The Hypothalamic–Pituitary–Thyroid axis (HPT) axis, is part of the neuroendocrine system responsible for the regulation of metabolism and also responds to stress. The interdependence between thyroid hormones, namely, thyroxine and triiodothyronine, and immune system is nowadays well-recognized . Thyroid diseases are common conditions that have a negative impact on the health of all populations. The literature sheds light on the differences in the composition of the intestinal microbiota in patients suffering from thyroid diseases compared to healthy individuals. The Hypothalamic–Pituitary–Adrenal (HPA) axis is emerging to closely interact with the gut microbiota. The hypothalamic-pituitary-adrenal (HPA) axis is a complex neuroendocrine system that plays a crucial role in the body's stress response and homeostasis regulation . Here's an overview of its key components and functions: 1. Hypothalamus 2. Pituitary gland 3. Adrenal glands When the body perceives stress, the following cascade of events occurs: The paraventricular nucleus of the hypothalamus releases corticotropin-releasing hormone (CRH) and vasopressin[1 ][3 ]. CRH stimulates the anterior lobe of the pituitary gland to secrete adrenocorticotropic hormone (ACTH)[1 ][3 ]. ACTH travels through the bloodstream to the adrenal cortex, where it stimulates the production and release of glucocorticoids, primarily cortisol in humans[1 ][3 ]. Functions and Regulation The HPA axis serves several important functions: Stress response: It mediates the body's physiological adaptation to stressors[1 ][2 ]. Homeostasis: It regulates various body processes, including metabolism, immune responses, and energy balance[1 ]. Circadian rhythm: It plays a role in maintaining the body's daily rhythms[2 ]. The HPA axis is regulated through negative feedback loops : Elevated cortisol levels inhibit further HPA axis activation by suppressing CRH and ACTH production in the hypothalamus and pituitary gland, respectively[3 ]. This feedback mechanism helps maintain appropriate cortisol levels and prevents overactivation of the stress response[3 ]. Clinical Significance Dysregulation of the HPA axis can lead to various health issues: Chronic stress can result in prolonged activation of the HPA axis, potentially leading to anxiety, depression, and other mood disorders[2 ]. Abnormal HPA axis function has been implicated in inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis[1 ]. HPA axis dysfunction may contribute to metabolic disorders and cardiovascular diseases[2 ]. Understanding the HPA axis is crucial for comprehending the physiological effects of stress and the potential long-term consequences of chronic stress on overall health and well-being. Low levels of gonadal circulating estrogen (Gonads are glands that produce hormones involved in reproduction and other functions of the body) observed in post-menopausal women can adversely impact a diverse range of physiological factors, with clinical implications for brain cognition, gut health, the female reproductive tract and other aspects of women's health. One of the principal regulators of circulating estrogens is the gut microbiome . "Recent advances show a relationship and possible cause and effect between the gut microbiota and the initiation or exacerbation of autoimmune diseases. Furthermore, microbial dysbiosis and leaky gut are frequent phenomena in both human autoimmune diseases and the murine autoimmunity models." Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoing an additional transition: pregnancy, which may or may not be accompanied by breastfeeding. These endocrinological transitions exert significant effects on the immune system due to interactions between the hormonal milieu, innate, and adaptive immune systems as well as pro- and anti-inflammatory cytokines, and thereby modulate the susceptibility of women to autoimmune diseases. "The human gut-resident commensal microbiota (our indigenous bacteria ) is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis (imbalance of gut microbiota associated with an unhealthy outcome ) plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases." This study (one out of many) "describes the bidirectional communication between the gut microbiota and the HPA (Hypothalamic–Pituitary–Adrenal) axis and delineates the potential underlying mechanisms." This Study , "discuss how the intestinal bacterial microbiome and in particular how an 'estrobolome,' the aggregate of enteric bacterial genes capable of metabolizing estrogens, might affect women's risk of developing postmenopausal estrogen receptor-positive breast cancer ." The above citations and references are presented to convince you that healthy gut microbiota is a prime element in the maintenance of healthy endocrine system. For more about HEALTHY MICROBIOTA read on this page. The Hypothalamic–Pituitary–Thyroid axis The Hypothalamic–Pituitary–Adrenal (HPA) axis Thyroid Disorder - Hypothyroidism Thyroid Disorder - Hypothyroidism A condition, typically affects people over 60 and is more common among women than men, where the thyroid gland no longer produces enough of the important metabolism-controlling hormones. Without the right amount of thyroid hormones the T4 and T3 ones, your body’s natural functions – like your cognitive functioning (Read more ) and metabolism – start deteriorating. T4 (thyroxine) and T3 (triiodothyronine) are crucial thyroid hormones that play vital roles in regulating various bodily functions. Here's an overview of their roles and importance: Metabolic Regulation T4 and T3 are essential for controlling metabolism throughout the body. They influence how cells use energy and regulate the body's overall metabolic rate[1 ][2 ]. This impacts various processes, including: Protein synthesis: Thyroid hormones help regulate protein production in cells. Carbohydrate metabolism: They influence how the body processes and uses carbohydrates. Fat metabolism: T3 and T4 play a role in fat breakdown and utilization. Growth and Development Thyroid hormones are critical for: Brain development: Especially crucial during fetal development and early childhood. Physical growth: They influence bone growth and maturation. Organ Function T3 and T4 affect the function of nearly every organ system in the body, including: Cardiovascular system: Regulating heart rate and cardiac output. Respiratory system: Influencing breathing rate and lung function. Digestive system: Affecting gut motility and nutrient absorption. Nervous system: Impacting cognitive function and mood. Temperature Regulation Thyroid hormones help maintain body temperature by influencing heat production and energy expenditure[2 ]. Hormone Interplay T4 as a prohormone: T4 serves primarily as a reservoir for T3, the more biologically active form[1 ]. Conversion process: Most T3 is produced by converting T4 to T3 in peripheral tissues, particularly the liver and kidneys[3 ]. Thyroid-Progesterone Interactions - The thyroid and progesterone can influence each other in several ways: Thyroid hormones affect the metabolism of steroid hormones, including progesterone. Hypothyroidism may lead to increased progesterone levels in some men. Progesterone can influence thyroid hormone binding in the bloodstream. Both hormones play roles in male fertility and reproductive function. Feedback Loop T3 and T4 participate in a complex feedback system involving the hypothalamus, pituitary gland, and thyroid gland to maintain hormonal balance[2 ][4 ]. Clinical Significance Imbalances in T3 and T4 levels can lead to various thyroid disorders: Hypothyroidism: Insufficient thyroid hormone production, leading to symptoms like fatigue, weight gain, and cold intolerance[5 ]. Hyperthyroidism: Excessive thyroid hormone production, causing symptoms such as anxiety, weight loss, and heat intolerance[5 ]. Understanding the roles of T3 and T4 is crucial for diagnosing and managing thyroid disorders, as well as comprehending their wide-ranging effects on overall health and well-being. Does hypothyroidism cause high cortisol (don't confuse it with cholesterol) levels? It has long been k nown that hypothyroidism causes elevated cortisol levels , presumably due to both decreased clearance and blunted negative feedback of cortisol on the hypothalamic-pituitary-adrenal axis. Hashimoto’s Thyroiditis In Hashimoto’s Thyroiditis, the immune system mistakenly attacks the thyroid gland. Over time, these autoimmune attacks destroy healthy thyroid tissue, reducing thyroid hormone production. Hashimoto’s thyroiditis is the most common cause of underactive thyroid in the United States. And while it mostly affects middle-aged women, it can affect anyone at any age. Hypothyroidism In Infants Although hypothyroidism most often affects middle-aged and older women, anyone can develop the condition, including infants. Initially, babies born without a thyroid gland or with a gland that doesn't work properly may have few signs and symptoms. When newborns do have problems with hypothyroidism, the problems may include: Yellowing of the skin and whites of the eyes (jaundice). In most cases, this occurs when a baby's liver can't metabolize a substance called bilirubin, which normally forms when the body recycles old or damaged red blood cells. A large, protruding tongue. Difficulty breathing. Hoarse crying. An umbilical hernia. As the disease progresses, infants are likely to have trouble feeding and may fail to grow and develop normally. They may also have: Constipation Poor muscle tone Excessive sleepiness When hypothyroidism in infants isn't treated, even mild cases can lead to severe physical and mental retardation. Hypothyroidism in children and teens In general, children and teens who develop hypothyroidism have the same signs and symptoms as adults do, but they may also experience: Poor growth, resulting in short stature Delayed development of permanent teeth Delayed puberty Poor mental development Hyperthyroidism is a condition causing your thyroid to produce too much thyroid hormone. This can cause normal bodily processes to speed up, such as your heart rate. It can also lead to weight loss and difficulty sleeping. Hyperthyroidism is far less common than hypothyroidism, affecting less than 1% of people over the age of 12. Just like hypothyroidism, though, hyperthyroidism tends to affect women and men over the age of 60. Thyroid Health : There are some supplements that could help with thyroid general health like Selenium (a mineral needed for thyroid hormone production), Iodine, Zinc, and Iron. BUT, first and foremost, its health is closely linked to a healthy body and gut microbiota - actions for microbiota health are prescribed on this linked page . Note! "the composition of the gut microbiota has an influence on the availability of essential micronutrients for the thyroid gland. Iodine, iron, and copper are crucial for thyroid hormone synthesis, selenium and zinc are needed for converting thyroxine (the thyroid hormone - T4) to triiodothyronine hormone (T3), and vitamin D assists in regulating the immune response. Those micronutrients are often found to be deficient in Autoimmune Thyroid Disease patients (AITDs), resulting in malfunctioning of the thyroid. Bariatric surgery can lead to an inadequate absorption of these nutrients and further implicates changes in thyroid stimulating hormone (TSH) and T3 levels. Supplementation of probiotics showed beneficial effects on thyroid hormones and thyroid function in general..." Read more here . Hypothyroidism In Infants Thyroid Health Melatonin and the Pineal Gland Melatonin and the Pineal Gland The Melatonin hormone , often referred to as the sleep hormone, is a central part of the body’s sleep-wake cycle. Its production increases with evening darkness, promoting healthy sleep and helping to orient the body’s circadian rhythm. Two forms of melatonin exist in the body – circulatory (produced by the pineal gland), and subcellular (produced inside the cells and mitochondria); the majority of melatonin in the body is subcellular. Absence of light stimulates production of melatonin from the pineal gland, however, the largest stimulus of subcellular melatonin is near infrared light (sunshine is the greatest source - Roughly 49% of solar radiation is infrared between 700nm-1mm!). Note! The antioxidant effects of melatonin are so strong, they are thought to be strong and more potent than glutathione [REF1 ], Vitamin C [REF2 ], and Vitamin E. Melatonin is also being studied in other areas of health, such as neurodegenerative diseases, cancers, and anti-aging in general

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